Nervous System Diseases

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Morton Neuroma

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1 injection of 1mL methylprednisolone \[40mg\]with 1 mL 2% lignocaine

weekly manipulations to the metatarsophalangeal joints of the forefoot for 6 weeks

a single injection of 1 mL methylprednisolone \[40 mg\] and 1 mL 2% lignocaine

methylprednisolone

The lesser MTPJs of the affected foot will be manually manipulated using a high velocity, low amplitude thrust technique.

manual manipulation

David G Cashley, BSc(Hons)Pod

This study compares manipulative therapy to steroid injection in the treatment of Morton's Neuroma.

The aim of this study is to establish whether manipulative therapy is an effective treatment for Morton's neuroma, a nerve entrapment in the foot. Steroid injection is the current gold standard conservative treatment for this condition. Therefore, a subject group shall be compared to a steroid injection intervention group. Outcomes will be compared using visual analogue pain scales -VAS, Foot Function Index questionnaires and algometric pressure threshold testing. An improvement in the manipulation group VAS of 20mm above the injection group shall be considered as the minimum worthwhile change as this has been identified as the minimum clinically important difference in pain between treatment groups in visual analogue pain scales.

Morton's Neuroma: Manipulation Versus Steroid Injection

Manipulation Versus Steroid Injection in the Treatment of Morton's Neuroma

A questionnaire to establish subjects level of function, pain and mobility changes over time

Patient reported outcome measurement tool to measure changes in foot pain over time

Measuring changes in self reported pain over time. 100mm scale with anchored prompts of "no pain" at 0mm and "worst pain ever" at 100mm

Measuring changes in pressure tolerance over time. A meter which reads how much change in pressure a joint can withstand before it registers discomfort

Queen Margaret University

Dundee Podiatry Clinic

Rare Diseases

Fatigue

Chronic Graft Versus Host Disease

Chiropractic care

Austin Garlinghouse

Yori Gidron, PhD

The primary aims of the proposed trial are centered around examining the feasibility of conducting a prospective, chiropractic intervention study on a population of cancer survivors living in and around Atlanta, Georgia. This includes evaluating various implementation outcomes including recruitment, adherence, tolerability, retention, acceptability, and data fidelity. The results of this trial will inform the design of a future randomized controlled trial (RCT) that has an increased focus on the efficacy/effectiveness of chiropractic care on chronic cancer-related fatigue (CCRF) and other cancer-related sequelae in cancer survivors.

Cancer remission is often marked by the cessation of curative-intent treatments (e.g., surgery, chemotherapy, radiotherapy, immunotherapy), however, troublesome signs and symptoms (e.g., fatigue, depression, cognitive impairment, dysautonomia) related to the cancer and its treatments commonly persist for prolonged periods (i.e., months to years). Of these, chronic cancer-related fatigue (CCRF) is one of the most frequently reported and debilitating symptoms. CCRF may be characterized as tiredness or exhaustion persisting for 3 or more months following the completion of the primary curative-intent cancer therapies which is independent on one's quantity or quality of rest and causes impairments in daily functioning and quality of life. Notably, although the mechanisms underlying CCRF are still unclear, there is some evidence that it may be related to autonomic dysregulation.

Irrespective of the cause(s), lack of identification of and treatment for CCRF and other chronic cancer-related sequelae is commonplace. Further, empirical data supporting the efficacy of interventions to remediate these issues are relatively sparse and urgently needed as the global population of cancer survivors continues to increase. Of note, although there is no universally accepted definition of 'cancer survivor', the investigators define it here as someone who has completed their primary curative-intent therapies and is cancer-free (i.e., has no evidence of active disease). This definition is in line with that of the European Organisation of Research \& Treatment of Cancer (EORTC) Survivorship Task Force and the EORTC Quality of Life Group.

Interestingly, a recent study suggested that a single chiropractic adjustment may mitigate lower extremity muscular fatigue during isometric exercise in young, healthy males. However, to the investigators' knowledge, the impact of chiropractic care on CCRF and other health-related challenges that burden cancer survivors has yet to be investigated.

Effects of Chiropractic on Chronic Cancer-related Fatigue

The Effects of Upper Cervical Chiropractic Care in Adult Cancer Survivors With Chronic Cancer-related Fatigue: a Feasibility Trial

Average number of participants recruited/enrolled per month

Average time lag between first lab assessment \& first chiropractic visit

Proportion of participants violating 1 or more pre-assessment lifestyle restrictions \& unable/unwilling to be rescheduled

Proportion of participants not attending at least 80% of their chiropractic sessions

Proportion of participants unable/unwilling to complete a given assessment

Proportion of participants completing the trial

Most common patient-related acceptability score for each assessment process/procedure

Proportion of acquisitions from a given assessment that are unsuitable for analysis

Most common clinician-rated acceptability score for each trial process/procedure

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Morton's Neuroma: Manipulation Versus Steroid Injection	NCT05707572	Morton Neuroma	methylprednisol... manual manipula...	18 Years -	Dundee Podiatry Clinic
Morton's Neuroma: Manipulation Versus Steroid Injection	NCT05707572	Morton Neuroma	methylprednisol... manual manipula...	18 Years -	Dundee Podiatry Clinic
Morton's Neuroma: Manipulation Versus Steroid Injection	NCT05707572	Morton Neuroma	methylprednisol... manual manipula...	18 Years -	Dundee Podiatry Clinic
Morton's Neuroma: Manipulation Versus Steroid Injection	NCT05707572	Morton Neuroma	methylprednisol... manual manipula...	18 Years -	Dundee Podiatry Clinic
Effects of Chiropractic on Chronic Cancer-related Fatigue	NCT06235671	Cancer Fatigue	Chiropractic ca...	18 Years - 65 Years	Life University

Spots Global Cancer Trial Database for manipulation

Every month we try and update this database with for manipulation cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.