Neoplasms

All Conditions

Rare Diseases

Glioma

Neoplasms, Neuroepithelial

Neuroectodermal Tumors

Neuroectodermal Tumors, Primitive

Neoplasms, Germ Cell and Embryonal

Neoplasms by Histologic Type

Neoplasms, Glandular and Epithelial

Neoplasms, Nerve Tissue

Neuroepithelioma

Analgesics

Central Nervous System Depressants

All Drugs and Chemicals

Adjuvants, Anesthesia

Psychotropic Drugs

Dexmedetomidine

Midazolam

Hypnotics and Sedatives

Analgesics, Non-Narcotic

Adrenergic Agents

Adrenergic alpha-Agonists

Adrenergic Agonists

Neurotransmitter Agents

Anesthetics

Anti-Anxiety Agents

Anesthetics, Intravenous

Anesthetics, General

GABA Modulators

The brain eloquent area glioma will be diagnosed by MRI scan.

Healthy volunteers without intracranial diseases.

Participant will be sedated by midazolam.

Participant will be sedated by dexmedetomidine.

Nan LIN, MD, PhD

Nan Lin, MD

中国

Nan LIN

It has been shown through functional MRI (Magnetic Resonance Imaging) that patients with gliomas in eloquent areas have compensated neurological function by virtue of brain post-injury reorganization. Our previous clinical research found that mild sedation could induce and/or exacerbate neurological deficits, especially in limb motor and ataxia function, in these patients presumably by impairing functional compensation,. Nevertheless it is still very unclear how mild sedation affects sensorimotor networks in brains where reorganization may be present. Since eloquent area glioma patients are frequently subjected to sedation, anesthetics, and neurological examinations perioperatively, it is important to investigate how mild sedation interacts with motor network reorganization and functional compensation. Our research in patients with eloquent area gliomas will utilize neurological evaluations and multimodal MRI to explore the changes in brain upper limb' motor network reorganization after mild sedation by different sedatives-anesthetics. The neurological evaluations include sensorimotor function scale and testing tool. Multimodal MRI consists of 3-dimentional structure, blood oxygen-level dependent for cortical activation and diffusion tensor imaging for subcortical conduction. The data from the clinical testing and functional MRI will be processed and analyzed along with other relevant clinical information. This research will answer the question of how mild sedation affects upper limb motor function networks in brains with eloquent area gliomas. This new information will help optimize perioperative anesthetic and sedative choice for patients with eloquent area gliomas.

The Effects of Mild Sedation on Motor Function Networks in Patients With Brian Gliomas

The Effects of Mild Sedation on Compensatory Upper Limb Motor Function Networks Based on Multimodal Magnetic Resonance Imaging in With Gliomas in Brain Eloquent Areas

will use 9-hole peg test and motor/sensory function evaluation

the detailed type of glioma and WHO glioma grade

Beijing Tiantan Hospital

Principal Investigator

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
The Effects of Mild Sedation on Motor Function Networks in Patients With Brian Gliomas	NCT03984240	Brain Glioma	Midazolam Dexmedetomidine	25 Years - 60 Years	Beijing Tiantan Hospital
The Effects of Mild Sedation on Motor Function Networks in Patients With Brian Gliomas	NCT03984240	Brain Glioma	Midazolam Dexmedetomidine	25 Years - 60 Years	Beijing Tiantan Hospital

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