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English Walnut

Patients will be randomized to receive walnuts

Patients will be randomized to receive almonds

Subjects will follow their usual diet for 4 weeks; after that they will be randomized to walnuts. They will eat walnuts once daily for six weeks.

walnuts

Subjects will follow their usual diet for 4 weeks; after that they will be randomized to almonds. They will eat almonds once daily for six weeks.

almonds

Sidika E Kasim-Karakas, MD

The purpose of this study is to learn more about the effects of walnuts, walnut-oil, almonds and fish oils on blood sugar and insulin levels in polycystic ovary syndrome (PCOS) patients. The hypothesis is that a diet rich in these foods will improve insulin resistance in women with PCOS.

Polycystic ovary syndrome is a common disease that affects 1 out of 16 women. Metabolic and endocrine abnormalities seen in PCOS include insulin resistance, androgen excess and infertility. This study focuses on the insulin resistance aspect because increased insulin resistance leads to premature onset of impaired glucose tolerance or diabetes whereas decreased insulin resistance reduces androgen excess, improves the ovarian function and increases fertility. Although insulin resistance can be treated with insulin-sensitizing drugs, PCOS clinically manifests during adolescence and the long-term safety of the drug-treatment can be a concern. Thus, improving insulin resistance with effective nutritional approaches would be very desirable. Epidemiological studies and animal experiments suggest that replacement of dietary saturated fats with monounsaturated (MUFA) and polyunsaturated (PUFA) fats improves insulin resistance.

The Effects of Walnuts, Walnut-Oil, Almonds and Fish Oils on Glucose Homeostasis in Polycystic Ovary Syndrome

Walnuts, Walnut-Oil, Glucose Homeostasis, PCOS

National Institutes of Health (NIH)

National Center for Complementary and Integrative Health (NCCIH)

University of California, Davis

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
The Effects of Walnuts, Walnut-Oil, Almonds and Fish Oils on Glucose Homeostasis in Polycystic Ovary Syndrome	NCT00579904	Polycystic Ovar... Insulin Resista...	walnuts almonds	18 Years - 45 Years	University of California, Davis
The Effects of Walnuts, Walnut-Oil, Almonds and Fish Oils on Glucose Homeostasis in Polycystic Ovary Syndrome	NCT00579904	Polycystic Ovar... Insulin Resista...	walnuts almonds	18 Years - 45 Years	University of California, Davis
The Effects of Walnuts, Walnut-Oil, Almonds and Fish Oils on Glucose Homeostasis in Polycystic Ovary Syndrome	NCT00579904	Polycystic Ovar... Insulin Resista...	walnuts almonds	18 Years - 45 Years	University of California, Davis
The Effects of Walnuts, Walnut-Oil, Almonds and Fish Oils on Glucose Homeostasis in Polycystic Ovary Syndrome	NCT00579904	Polycystic Ovar... Insulin Resista...	walnuts almonds	18 Years - 45 Years	University of California, Davis

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