Central Nervous System Depressants

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Participants use an activity monitor and the interactive website. They will receive minimal rewards based on their physical activity levels.

Participants use an activity monitor and the interactive website.

In addition to minimal rewards, participants will receive immediate incentives as they move from one level to the other on the website.

Participants in the control group will receive an activity monitor and educational materials, but will not have access to the interactive website. No rewards will be offered for their participation.

Activity Monitor

Zamzee is a meter that measures activity and a website that makes moving fun. Parents of participants can set activity goals. Activity is uploaded to the website where participants track progress and earn rewards by increasing their level of activity. Participants can view leaderboards and check how other participants are doing.

Interactive Website

All participants will receive educational handouts about physical activity. Participants will receive the educational handouts again via mail three and five months into the study to reinforce the importance of physical activity and maintain compliance.

Educational Materials

Kirsten K. Ness, PT, PhD

Five year survival following a diagnosis of childhood cancer has reached 83%, making long term health outcomes among survivors an important concern. The growing population of survivors is at an increased risk of physical inactivity and associated adverse health outcomes. Regular physical activity is associated with better cardiovascular and musculoskeletal health. Despite the known benefits of physical activity, nearly half of all childhood cancer survivors do not meet recommended guidelines for physical activity.

Researchers at St. Jude Children's Research Hospital (SJCRH) want to determine if a rewards-based physical activity intervention delivered via an interactive website among young adolescent childhood cancer survivors, aged 11 through 14 years, will increase physical activity levels and improve cardiovascular and musculoskeletal health. The investigators also want to learn if this rewards-based intervention is effective. To achieve this goal the investigators have designed a three-arm prospective, randomized study with two reward-based intervention groups and a control group.

PRIMARY OBJECTIVE:

* To compare changes in levels of moderate and vigorous physical activity over 24 weeks.

SECONDARY OBJECTIVE:

* To compare changes in cardiorespiratory fitness, muscular strength and flexibility over 24 weeks.

Participants will be randomized to one of three groups. Participants in the control group will receive an activity monitor and educational materials, but will not have access to the interactive website. Participants randomized to the two intervention groups will be given access to a rewards program delivered via an interactive website, an activity monitor, and educational materials. Individual physical activity data can be viewed by study participants after uploading information from their monitors to the interactive website. One intervention group will receive minimal rewards, while the other group will receive immediate incentives as well as the minimal rewards as they move from one level to the other on the website.

After 24 weeks, changes in cardiorespiratory fitness, muscular strength, flexibility, and physical function will be compared between the two intervention groups and the control group.

A Web-Based Physical Activity Intervention in Adolescent Survivors of Childhood Cancer

A Randomized Web-Based Physical Activity Intervention in Adolescent Survivors of Childhood Cancer

The impact of the intervention was assessed at the end of 24 weeks by comparing the mean difference in physical activity levels from baseline to 24-weeks between groups.

The difference in mean change in peak oxygen uptake from baseline to 24-weeks was compared between groups.

The difference in mean changes of sit and reach from baseline to 24-weeks was compared between groups

The difference between mean changes from baseline to 24-weeks in active dorsiflexion was compared between groups.

The difference from baseline to 24-weeks in mean changes in grip strength (kilograms) was compared between groups.

The number of sit-ups completed in 30 seconds was assessed, and the differences from baseline to 24-weeks in mean changes on the strength subtests of the Bruininks-Oseretsky Test of Motor Proficiency were compared between groups.

The number of push-ups completed in 30 seconds was assessed, and the differences from baseline to 24-weeks in mean changes on the strength subtests of the Bruininks-Oseretsky Test of Motor Proficiency were compared between groups.

The difference from baseline to 24-weeks in mean changes in knee extension strength 60 degrees per second (Newton meters) was compared between groups.

The difference from baseline to 24-weeks in mean changes in knee extension strength 120 degrees per second (Newton meters) was compared between groups.

The difference from baseline to 24-weeks in mean changes in knee extension strength at 180 degrees per second (Newton meters) was compared between groups

The differences from baseline to 24-weeks in mean changes in ankle dorsiflexion strength 30 degrees per second (Newton meters) was compared between groups.

The differences from baseline to 24-weeks in mean changes in ankle dorsiflexion strength at 60 degrees per second (Newton meters) was compared between groups.

St. Jude Children's Research Hospital

Participants use an activity monitor and the interactive website. They will receive minimal rewards based on their physical activity levels.

Activity Monitor: Measurement of physical activity.

Interactive Website: Zamzee is a meter that measures activity and a website that makes moving fun. Parents of participants can set activity goals. Activity is uploaded to the website where participants track progress and earn rewards by increasing their level of activity. Participants can view leaderboards and check how other participants are doing.

Educational Materials: All participants will receive educational handouts about physical activity. Participants will receive the educational handouts again via mail three and five months into the study to reinforce the importance of physical activity and maintain compliance.

Group A: Minimal Rewards

Participants use an activity monitor and the interactive website.

In addition to minimal rewards, participants will receive immediate incentives as they move from one level to the other on the website.

Activity Monitor: Measurement of physical activity.

Interactive Website: Zamzee is a meter that measures activity and a website that makes moving fun. Parents of participants can set activity goals. Activity is uploaded to the website where participants track progress and earn rewards by increasing their level of activity. Participants can view leaderboards and check how other participants are doing.

Educational Materials: All participants will receive educational handouts about physical activity. Participants will receive the educational handouts again via mail three and five months into the study to reinforce the importance of physical activity and maintain compliance.

Group B: Immediate Incentives

Participants in the control group will receive an activity monitor and educational materials, but will not have access to the interactive website. No rewards will be offered for their participation.

Activity Monitor: Measurement of physical activity.

Educational Materials: All participants will receive educational handouts about physical activity. Participants will receive the educational handouts again via mail three and five months into the study to reinforce the importance of physical activity and maintain compliance.

Group C: Control

Total

Age, Continuous

Age at diagnosis

Time since diagnosis

Age, Customized

Sex: Female, Male

Non-White

White

Race/Ethnicity, Customized

Leukemia

Central Nervous System Tumor

Lymphoma

Retinoblastoma

Other Solid Tumor

Diagnosis

Daily Moderate to Vigorous Physical Activity (MVPA)

Body mass index (BMI)

Resting heart rate (HR)

Resting respiratory rate (RR)

Systolic

Diastolic

Blood pressure (BP)

Peak VO2 is a measure of exercise capacity: volume of oxygen uptake per minute adjusted for weight.

Peak VO2

Sit and reach is a measure of low back and hamstring flexibility.

Sit and reach

Active dorsiflexion is a measure of ankle flexibility.

Active dorsiflexion

Hand grip is a measure of how much muscle power a person can generate gripping an object.

Hand grip

This measure assessed the number of sit-ups done in 30 seconds.

Sit-up

This measure assessed the number of push-ups done in 30 seconds.

Spots Global Cancer Trial Database for musculoskeletal health