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Soft Tissue Sarcoma

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Pyruvate

Injection with hyperpolarized 13CPyruvate followed by gadolinium during MRSI.

Bolus injection of study drug during MRSI.

Hyperpolarized 13CPyruvate

Investigators will determine whether MRSI using hyperpolarized \[1-13C\]pyruvate provide useful information of tumor malignancy in MRI-indeterminate cases. Metabolite maps of hyperpolarized \[1-13C\]lactate and H13CO3- produced from hyperpolarized \[1-13C\]pyruvate will be compared to the biopsy results of MRI-indeterminate patients and the 13C-maps of age-matched healthy subjects.

A non-randomized, interventional (nontherapeutic), feasibility trial to detect metabolic changes in participants with musculoskeletal sarcoma using hyperpolarized \[1-13C\]pyruvate Magnetic Resonance Spectroscopy Imaging (MRSI). All measured quantities will be tabulated and the analysis will be descriptive and obervational in nature.

Participants in this study will receive the study drug, hyperpolarized \[1-13C\]pyruvate, as a bolus injection during an MRSI of either a soft tissue sarcoma or healthy tissue. After the study drug injection and MRSI, participants will then receive contrast material, Gadavist, via injection during continuation the MRI.

Metabolic Characteristics of Sarcoma In Vivo Using HP 13-C Magnetic Resonance Spectroscopic Imaging (MRSI)

Investigating Metabolic Characteristics of Musculoskeletal Sarcoma In Vivo Using Hyperpolarized Carbon-13 Magnetic Resonance Spectroscopic Imaging (MRSI)

How much metabolic contrast can be detected using hyperpolarized Carbon-13 pyruvate

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Metabolic Characteristics of Sarcoma In Vivo Using HP 13-C Magnetic Resonance Spectroscopic Imaging (MRSI)	NCT03759704	Sarcoma, Soft T...	Hyperpolarized ...	18 Years - 100 Years	University of Texas Southwestern Medical Center
Metabolic Characteristics of Sarcoma In Vivo Using HP 13-C Magnetic Resonance Spectroscopic Imaging (MRSI)	NCT03759704	Sarcoma, Soft T...	Hyperpolarized ...	18 Years - 100 Years	University of Texas Southwestern Medical Center
Metabolic Characteristics of Sarcoma In Vivo Using HP 13-C Magnetic Resonance Spectroscopic Imaging (MRSI)	NCT03759704	Sarcoma, Soft T...	Hyperpolarized ...	18 Years - 100 Years	University of Texas Southwestern Medical Center

Spots Global Cancer Trial Database for musculoskeletal sarcoma