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radio-labelled (I-125) titanium seed inserted via needle into nonpalpable breast lesion and gamma probe used to guide surgery

radioguided seed localization for nonpalpable breast cancers

Peter J Lovrics, MD

Mary Townsend

The purpose of this study is to determine whether a new surgical technique (radioguided seed localization) for localizing nonpalpable breast tumours is better than the standard technique (needle localization).

Most breast cancers are removed by partial mastectomy/lumpectomy. The most important factor in ensuring that the cancer does not return in the breast is to ensure that it is completely removed during surgery. Complete removal is dependent on having a rim of normal tissue (clear margin) surrounding the cancer. If the margin is positive, or the cancer recurs, more surgery or mastectomy is required. Approximately one third of breast cancers are detected by mammograms or ultrasounds and cannot be felt by patients or physicians. Accordingly, a localization technique is required to help the surgeon to find and remove the cancer. The current technique (needle localization) has a higher chance of having cancer cells at the margin. This is a study about a surgical technique. The objective of this comparison study is to determine whether a new technique (radioguided seed localization) is a better way to remove nonpalpable breast cancers. The main objective of this study is to determine if the new technique generates fewer positive margins compared to the standard technique. An improved technique would benefit thousands of women every year.

Trial Comparing Radioactive Seed Localization to Standard Procedure for Non-palpable Breast Cancers

A Prospective, Randomized, Controlled Trial of Radioguided Seed Localization Versus Standard Needle Localization of Nonpalpable Breast Cancers

Canadian Breast Cancer Foundation

McMaster University

Dr. Peter J. Lovrics

Respiratory Tract (Lung and Bronchial) Diseases

Lung Neoplasms

Multiple Pulmonary Nodules

Antineoplastic Agents

All Drugs and Chemicals

Ethiodized Oil

Needle localization for deep-seated lung nodules with microcoil placement

Needle localization for deep-seated lung nodules with contrast injection

Microcoil

Needle localization with contrast injection

Lipiodol

Chiu-kuei Nien

In recent years, the development of low-dose pulmonary computed tomography screening has led to the discovery of many small pulmonary nodules in the early stages.

Surgical resection is still the main treatment for those suspected malignant lesions. In the face of such small pulmonary nodules, accurate preoperative localization has become the key to successful resection, and the deep-seated nodules are the most challenging parts. Because the deep-seated nodules cannot be localized by surface dye injection, however, it is necessary to place a fiducial marker (such as a microcoil) or contrast medium injection in combination with intraoperative fluoroscopy to ensure adequate resection of the deep-seated nodules. . This study will be carried out at the Hsinchu Branch of National Taiwan University Hospital. It is expected that 60 patients with pulmonary nodules with a depth larger than 2 cm will be randomly assigned into two groups. One group will receive microcoil placement, and the other group will receive contrast medium injection. The primary goal of the study was to compare the localization duration of the two groups of patients, the total dose of radiation exposure during localization and the incidence of location-related complications, and the secondary goals were the results of the surgical procedure, including the surgical duration.

Localization for Deep Lung Nodules: Microcoil Versus Contrast Injection

Preoperative Localization With Microcoil Placement or Contrast Injection for Deep-seated Pulmonary Nodule : A Prospective Randomized Trial

Procedure success is defined as marking (lipiodol or hook-wire) the GGO lesion within 1 cm without pleural leakage of lipiodol or dislodgement of the hook-wire. The procedure success rate is calculated as follows: procedure success rate (%) = (number of procedure success / number of total procedure) × 100.

Incidence of complications during needle procedure, The procedure-related complication rate is calculated as follows: procedure-related complication rate (%) = (number of procedure-related complication / number of total procedure) × 100.

From start of needle procedure to withdraw of the needle (minutes)

From start of surgery to completion of pulmonary wedge resection (minutes)

Distance from pulmonary lesion to resection margin of the specimen

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Trial Comparing Radioactive Seed Localization to Standard Procedure for Non-palpable Breast Cancers	NCT00225927	Breast Cancer I... Stage 0 Breast ...	radioguided see...	18 Years -	McMaster University
Localization for Deep Lung Nodules: Microcoil Versus Contrast Injection	NCT03617029	Lung Cancer	Microcoil Lipiodol	20 Years - 90 Years	National Taiwan University Hospital Hsin-Chu Branch
Localization for Deep Lung Nodules: Microcoil Versus Contrast Injection	NCT03617029	Lung Cancer	Microcoil Lipiodol	20 Years - 90 Years	National Taiwan University Hospital Hsin-Chu Branch

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