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Breast cancer survivors ages 50-70 with AJCC stages 0-3 breast cancer who are at least 1 year post-treatment (including surgery, radiation, and chemotherapy, with or without current endocrine therapy)

Healthy controls ages 50-70 with no history of cancer.

James Root, PhD

The purpose of this study is to observe the attention and memory processes in breast cancer survivors. Both cancer survivors and healthy volunteers (who are the same age as the cancer survivors) will participate in this study so we can compare the results of testing on each group of participants.

Survivors will be recruited in Breast Medicine Service clinics at the Breast and Imaging Center

A Study of Attention and Memory Processes in Breast Cancer Survivors

Neural and Cognitive Mechanisms of Attention and Memory Deficits in Cancer Survivors

Memorial Sloan Kettering Cancer Center supports the international committee of medical journal editors (ICMJE) and the ethical obligation of responsible sharing of data from clinical trials. The protocol summary, a statistical summary, and informed consent form will be made available on clinicaltrials.gov when required as a condition of Federal awards, other agreements supporting the research and/or as otherwise required. Requests for deidentified individual participant data can be made beginning 12 months after publication and for up to 36 months post publication. Deidentified individual participant data reported in the manuscript will be shared under the terms of a Data Use Agreement and may only be used for approved proposals. Requests may be made to: crdatashare@mskcc.org.

Using EEG measures of brain activity during a cognitive-experimental long-term memory task to evaluate the mechanisms underlying attention, initial learning, retrieval, and metamemory performance. P3 amplitude as measured by EEG at the Pz electrode.

During passive tasks (such as a paired-click paradigm)The proposed paradigm is adapted from previous work using EEG to measure the relationship between attention, learning, and subsequent performance on a verbal long-term memory task in healthy adults41. Relative to standard neuropsychological measures, this technique provides a more finely grained approach to investigating the effect of attentional mechanisms on subcomponents of initial learning and retrieval processes in long-term memory.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
A Study of Attention and Memory Processes in Breast Cancer Survivors	NCT04883398	Breast Cancer S...		50 Years - 70 Years	Memorial Sloan Kettering Cancer Center
A Study of Attention and Memory Processes in Breast Cancer Survivors	NCT04883398	Breast Cancer S...		50 Years - 70 Years	Memorial Sloan Kettering Cancer Center

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