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GROUP B 1-3 days after any chemotherapy that may activate viral TK, 4 mCi of I-FIAU are administered, followed 2 - 4 hours later by FIAU-PET-CT-4.

GROUP A 1-3 days after any chemotherapy that may activate viral TK, 2 mCi of I-FIAU are administered, followed 2 - 4 hours later by FIAU-PET-CT-2.

1-3 days after chemotherapy, subject get I-FIAU 2 mCi, then have FIAU-PET-CT done 2 - 4 hours after I-FIAU

FIAU-PET-CT-2

1-3 days after any chemotherapy that may activate viral TK, 4 mCi, rather than 2 mCi, of I-FIAU are administered, followed 2 - 4 hours later by FIAU-PET-CT

FIAU-PET-CT-4

Richard Ambinder, M.D.

This research is being done to determine whether viral thymidine kinase (TK) expression in Epstein-Barr virus (EBV) and Kaposi's sarcoma herpesvirus (KSHV) virus-associated tumors is sufficient to image.

EBV and KSHV are associated with a variety of malignancies including some lymphomas, carcinomas and other malignancies. We anticipate that viral TK expression will differ among tumor types and will be adjusted with standard chemotherapies and some investigational agents. This exploratory study is aimed in part at evaluating whether standard regimens or investigational regimens might bring about sufficient activation of the EBV-TK or KSHV-TK in tumors to be therapeutically useful if used in conjunction with FIAU as a radiopharmaceutical.

124I-FIAU Imaging in EBV and KSHV Associated Cancers

Study of Imaging of Viral Thymidine Kinase Activity in EBV-Associated and KSHV-Associated Malignancies

National Cancer Institute (NCI)

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
124I-FIAU Imaging in EBV and KSHV Associated Cancers	NCT00982449	Hodgkin Lymphom... Non Hodgkin Lym... Kaposi's Sarcom... Gastric Cancer Nasopharyngeal ...	FIAU-PET-CT-2 FIAU-PET-CT-4	18 Years - 75 Years	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
124I-FIAU Imaging in EBV and KSHV Associated Cancers	NCT00982449	Hodgkin Lymphom... Non Hodgkin Lym... Kaposi's Sarcom... Gastric Cancer Nasopharyngeal ...	FIAU-PET-CT-2 FIAU-PET-CT-4	18 Years - 75 Years	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

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