Neoplasms

Symptoms and General Pathology

All Conditions

Digestive System Diseases

Neoplasm Metastasis

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Rectal Diseases

Central Nervous System Depressants

All Drugs and Chemicals

Anesthetics

Patients with metastatic colorectal cancer scheduled for metastatic surgery

Patients with metastatic colorectal cancer scheduled for general anesthesia without metastatic surgery

Observational, non randomized study aimed at measuring the effect of surgical resection of metastasis in the urinary concentrations of physiological modified nucleosides in 45 patients with metastatic colorectal cancer.

"Cancersensor" Metastasis Resection

Molecularly Imprinted Polymer Sensors of Modified Nucleosides for Non-invasive Monitoring, of Cancer Therapy: Impact of Surgical Resection of Metastasis on Urinary Excretion of Modified Nucleosides.

1 Urine sample per day 3 before and 7 after surgery Measurement of modified nucleoside concentration

Measurement of modified nucleosides in urine samples before and after metastatic resection

Institut National de la Santé Et de la Recherche Médicale, France

Patients with metastatic colorectal cancer treated with chemotherapy

Francis Lévi, MD PhD

Observational, non randomized study aimed at measuring the effect of chemotherapy in the urinary concentrations of physiological modified nucleosides in 30 patients with metastatic colorectal cancer.

"Cancersensor" Chemotherapy

Molecularly Imprinted Polymer Sensors of Modified Nucleosides for Non-invasive Monitoring of Cancer Therapy : Effect of Chemotherapy on Cancerous Proliferation Based on the Dynamic Excretion of Urinary Nucleosides.

Measurement of modified nucleosides, cortisol and 6-sulfatoxymelatonin concentration in urine samples before and after chemotherapy

1 saliva sample Measurement of Clock genes polymorphisms expression

1 urine sample per day 3 days before and 14 days after beginning of chemotherapy Measurement of modified nucleosides, cortisol and 6-sulfatoxymelatonin concentration

1 saliva sample : Measurement of Clock genes polymorphisms expression

Blood and Lymph Conditions

Immune System Diseases

Rare Diseases

Leukemia

Leukemia, Lymphoid

Hematologic Neoplasms

Leukemia, Lymphocytic, Chronic, B-Cell

Lymphoproliferative Disorders

Neoplasms by Histologic Type

Hematologic Diseases

Leukemia, B-Cell

Lymphatic Diseases

Immunoproliferative Disorders

Chronic Disease

Disease Attributes

Chronic Graft Versus Host Disease

Chronic Lymphocytic Leukemia

Acute Graft Versus Host Disease

Antineoplastic Agents

Anti-Infective Agents

Fludarabine

Fludarabine phosphate

Vidarabine

Clofarabine

Cladribine

Antimetabolites

Hagop M. Kantarjian, M.D.

This is a dose-escalation study to determine the maximum tolerated dose and toxic effects of clofarabine in patients with chronic lymphocytic leukemia and other acute leukemias. Clofarabine is a synthesized hybrid nucleoside analog, which is believed to possess the better qualities of fludarabine and chlorodeoxyadenosine, the 2 most active agents against lymphoproliferative disorders. Thus, it is hoped that this drug will be more active and less toxic than similar drugs.

The first group of patients will be treated at the starting dose level of 2 mg/m2 over 1 hour daily for 5 days. Dosage escalation will be permitted in individual patients if no toxicity occurred during the preceding course. Subsequent dose escalations will be by 50% until Grade 2 toxicity, then by 35% until the maximum tolerated dose.

Completion date provided represents the completion date of the grant per OOPD records

Clofarabine in Chronic Lymphocytic Leukemia

Phase I Study of CL-F-ARA-A in Solid and Hematologic Malignancies

M.D. Anderson Cancer Center

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
"Cancersensor" Metastasis Resection	NCT01693848	Metastatic Colo...		18 Years -	Institut National de la Santé Et de la Recherche Médicale, France
"Cancersensor" Metastasis Resection	NCT01693848	Metastatic Colo...		18 Years -	Institut National de la Santé Et de la Recherche Médicale, France
"Cancersensor" Chemotherapy	NCT01693861	Metastatic Colo...		18 Years -	Institut National de la Santé Et de la Recherche Médicale, France
"Cancersensor" Chemotherapy	NCT01693861	Metastatic Colo...		18 Years -	Institut National de la Santé Et de la Recherche Médicale, France
Clofarabine in Chronic Lymphocytic Leukemia	NCT00028418	Hematologic Neo... Lymphoprolifera... Leukemia Leukemia, Lymph...	Clofarabine	18 Years -	FDA Office of Orphan Products Development

Spots Global Cancer Trial Database for nucleosides

Every month we try and update this database with for nucleosides cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for nucleosides

Every month we try and update this database with for nucleosides cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for nucleosides cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.