Nutritional and Metabolic Diseases

Gland and Hormone Related Diseases

All Conditions

Symptoms and General Pathology

Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Diabetes Mellitus, Type 2

Diabetes Mellitus

Syndrome

Obesity

Polycystic Ovary Syndrome

Insulin Resistance

Endometriosis

Fallopian Tube Diseases

Hyperinsulinism

Metabolic Diseases

Glucose Metabolism Disorders

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Cysts

Ovarian Cysts

Ovarian Diseases

Adnexal Diseases

Gonadal Disorders

Endocrine System Diseases

Hypoglycemic Agents

All Drugs and Chemicals

Insulin

Insulin, Globin Zinc

This group/cohort will have subjects having infertility due to PCOS (as per Rotterdam criteria)

This group/cohort will have subjects without PCOS but with any other diagnosis of infertility or any other complain.

Manchi R Bharucha, Ph.D

Manchi R Bharucha, Ph.D.

Women with PCOS have been observed to be potential diabetics.Recently,American Diabetes Association has suggested screening of women with PCOS for HbA1C.

In view of recent suggestion of American Diabetes Association(ADA)to screen women with PCOS for HbA1C,we intend to study its prevalence in all categories of obesity in women with PCOS.

Women with PCOS by Rotterdam criteria will be screened for insulin resistance by using different techniques or tests.

Further, the sensitivity and specificity of HbA1C will be compared with sensitivity and specificity of other insulin resistance markers such as OGTT, Free androgen index, free testosterone, fasting insulin to glucose ratio, HOMA-IR and HOMA-B-CELL.

Prevalence of HbA1C in Women With PCOS

Prevalence of HbA1C in Different Categories of Obesity in Women With PCOS'A Propective Randomized Control Study

HbA1C has been suggested as a potential marker for NIDDM in subjects with PCOS

Southern Cross Fertility Centre

Faram E.Irani

Diabetes, Gestational

Women without risk factors for GDM are offered OGTT in gestational week 28

Women with risk factors for OGTT are offered diagnostic 2 hour OGTT in pregnancy week 28

OGTT by randomization

OGTT by indication

Marianne Andersen, DMSci

Women with polycystic ovary syndrome (PCOS) are often insulin resistant. During pregnancy, insulin sensitivity decreases. The investigators examine glucose metabolism during oral glucose tolerance test and the incidense of gestational diabetes mellitus in a prospective cohort of pregnant women with PCOS and controls.

Screening for GDM in Women With PCOS and Controls

Glucose Metabolism and Screening for Gestational Diabetes Mellitus According to Different Sets of Criteria in Women With Polycystic Ovary Syndrome and Controls

Gestational diabetes mellitus diagnosed by oral glucose tolerance test in gestational week 28 in women with and without risk factors for gestational diabetes mellitus.

Gestational diabetes mellitus is diagnosed by 2 hour 75 gram oral glucose tolerance test in gestational week 28

The association between blood glucose values and anthropometric measures (birth length, weight and abdominal circumference) at birth in the offspring is investigated

Region of Southern Denmark

Municipality of Odense

University of Southern Denmark

Odense University Hospital

DMSci

Diseases and Abnormalities at or Before Birth

Rare Diseases

Hyperandrogenism

Disorders of Sex Development

46, XX Disorders of Sex Development

Congenital Abnormalities

Urogenital Abnormalities

Adrenal Hyperplasia, Congenital

Adrenogenital Syndrome

Male Urogenital Diseases

Congenital Adrenal Hyperplasia

21-hydroxylase Deficiency

Androgens

Progesterone

Complement System Proteins

Complement Factor H

Immunosuppressive Agents

Immunologic Factors

Arm 1 Breakfast Diet The arm 1 will be assigned to eat High calorie breakfast (800kcal) and reduced dinner (200 kcal) During 90 days from baseline to the end of the trial (day 90)

Lean PCOS women in the Arm 2 will be assigned to do a dinner diet from day 0 to day 90 of the trial

In this Arm 2 group the PCOS will be assigned to dinner diet and we will compare the androgen levels Day 0 to androgen after DAY 90 of this diet also we will compare Glucose and Insulin response to OGTT Day 0 and Day 90, and ovulatory frequency along alll the 90 days of the Dinner diet

Placebo Comparator: Lifestyle counseling Dinner Diet ARM 2

In the Arm 1 we will measure androgen levels and insulin and glucose response to OGTT at baseline DAY 0 and after 90 days on the dinner diet (Day 90) for comparison Also we will evaluate by weekly progesterone the ovulatory events

Active Comparator: Lifestyle counseling ARM 1

Daniela Jakubowicz, MD

The objective of this study is to investigate the effects of two isocaloric maintenance diets with different meal timing distribution on insulin resistance hyperandrogenism and cytochrome P450c17 alpha activity in lean PCOS women.

The investigators hypothesis is that in lean PCOS women a Breakfast Diet (BD) which consist in high calorie breakfast and reduced dinner, vs Dinner Diet (DD) which consist in high calorie dinner with reduced breakfast; the BD will improve glucose and insulin response to OGTT and would decrease the hyperandrogenism and cytochrome P450c17 alpha activity.

Hyperinsulinemia plays a central role in the pathogenesis in obese as well as in lean PCOS women. These women are insulin resistant and have compensatory hyperinsulinemia that stimulates ovarian cytochrome P450c17 alpha activity that in turn stimulates ovarian androgen concentrations.

In obese PCOS women, weight loss improves insulin resistance and hyperandrogenism, resulting in improvement of clinical symptoms.

Since lean PCOS women do not have the option of weight loss, it is important to know if composition and meal timing distribution may influence glucose metabolism and hyperandrogenism and cytochrome P450c17 alpha activity. We hypothesized that a timing pattern of increased nutrient intake of protein and carbohydrates in the morning, with decreased caloric intake at night would improve insulin sensitivity and hyperandrogenism in lean women with PCOS

Meal Timing on Glucose and Hyperandrogenism in PCOS Women

Influence of Meal Timing on Glucose Metabolism and Hyperandrogenism in Lean Women With Polycystic Ovary Syndrome

From baseline (day O) to the end of the study (day 90) progesterone will be quantified weekly to assess the ovulation in both of the group (The ovulation in the breakfast diet group will be compared to that of the dinner diet group)

The androgens (testosterone, free testosterone, DHEA-S, androstenedione)and 17 alpha hydroxyprogesterone will be measured at baseline and again will be measured at the end of the trial by day 90. In both groups or Arms one on breakfast diet and the other on dinner diet.

Glucose and Insulin Response to OGTT will be measured at baseline and again will be repeated after 90 days of the trial for comparison One group will be assigned to breakfast diet and the other group to dinner diet

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Prevalence of HbA1C in Women With PCOS	NCT01838122	Polycystic Ovar... Pelvic Endometr... Insulin Resista... Non-insulin Dep... Tubal Obstructi...		15 Years - 40 Years	Southern Cross Fertility Centre
Screening for GDM in Women With PCOS and Controls	NCT02183558	Polycystic Ovar... Gestational Dia...	OGTT by randomi... OGTT by indicat...	18 Years -	Odense University Hospital
Prevalence of HbA1C in Women With PCOS	NCT01838122	Polycystic Ovar... Pelvic Endometr... Insulin Resista... Non-insulin Dep... Tubal Obstructi...		15 Years - 40 Years	Southern Cross Fertility Centre
Screening for GDM in Women With PCOS and Controls	NCT02183558	Polycystic Ovar... Gestational Dia...	OGTT by randomi... OGTT by indicat...	18 Years -	Odense University Hospital
Meal Timing on Glucose and Hyperandrogenism in PCOS Women	NCT01711476	Polycystic Ovar...	Placebo Compara... Active Comparat...	22 Years - 50 Years	Hospital de Clinicas Caracas

Spots Global Cancer Trial Database for ogtt

Every month we try and update this database with for ogtt cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for ogtt

Every month we try and update this database with for ogtt cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for ogtt cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.