Symptoms and General Pathology

All Conditions

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Neoplasms

Gland and Hormone Related Diseases

Syndrome

Infertility

Polycystic Ovary Syndrome

Cysts

Ovarian Cysts

Ovarian Diseases

Adnexal Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Gonadal Disorders

Endocrine System Diseases

Hypoglycemic Agents

All Drugs and Chemicals

Anticoagulants

Reproductive Control Agents

Other Dietary Supplements

Metformin

Citric Acid

Sodium Citrate

Clomiphene

Enclomiphene

Zuclomiphene

Citrate

Metformin and FSHr

Ovarian drilling by FERTILOSCOPY

Hervé FERNANDEZ, MD,PhD

Hervé FERNANDES, MD,PhD

Hervé FERNANDEZ, MD

PolysCsytic Ovaries Syndrome (PCOS) is the most frequent endocrinopathy. The first stage of infertility treatment is Clomiphene Citrate which leads to 50 % pregnancies. In case of failure, it is possible to propose surgical ovarian drilling or ovarian hyperstimulation with Intra Uterine Insemination (IUI) which lead to 50% pregnancies each. However, surgical treatment could be associated to surgical complications, and medical treatment could be associated to ovarian hyperstimulation syndrome and/or multiple pregnancies.

The aim of this study is to compare the two treatments to demonstrate the equivalence of efficacy and the diminution of multiple pregnancies by the surgical treatments. After an ambulatory surgery we will observe the spontaneous fertility during 9 months. For the medical treatment, Metformin is proposed during 9 months associated with 3 cycles of ovarian hyperstimulation and IUI if the sperm is normal

PolysCsytic Ovaries Syndrome (PCOS) is the most frequent endocrinopathy. The first stage of infertility treatment is Clomiphene Citrate which leads to 50 % pregnancies. In case of failure, it is possible to propose surgical ovarian drilling or ovarian hyperstimulation with Intra Uterine Insemination (IUI) which lead to 50% pregnancies each. However, surgical treatment could be associated to surgical complications, and medical treatment could be associated to ovarian hyperstimulation syndrome and/or multiple pregnancies.

The aim of this study is to compare the two treatments to demonstrate the equivalence of efficacy and the diminution of multiple pregnancies by the surgical treatments. After an ambulatory surgery we will observe the spontaneous fertility during 9 months. For the medical treatment, Metformin is proposed during 9 months associated with 3 cycles of ovarian hyperstimulation and IUI if the sperm is normal Ovarian drilling will be performed by FERTILOSCOPY. 126 patients will be necessary in each group (with interval of equivalence : 10%).

Surgical Ovarian Drilling Versus Hormonal Treatment for Infertility Associated to PolyCystic Ovaries Syndrome (PCOS)

PERCING : Ovarian Drilling Versus Ovarian Stimulation + Intra Uterine Insemination (IUI) + Metformin in the PCOS (PolyCystic Ovaries Syndrome) Treatment

Hopital Antoine Beclere

Hôpital Jean Verdier

Jean Rostand Intercommoned Hospital

Centre Hospitalier Universitaire, Amiens

University Hospital, Caen

University Hospital, Clermont-Ferrand

Lille Hospital : Jeanne de Flandre Hospital

University Hospital, Strasbourg, France

CMCO SIHCUS, Schiltingheim

Study and research center of sterility (Lyon)

Assistance Publique - Hôpitaux de Paris

Micronutrients

Hematinics

Vitamins

Inositol

Folic Acid

Vitamin B Complex

Trace Elements

Folinic Acid

Folate

Vitamin B9

standard ovarian stimulation and Inofolic®

standard ovarian stimulation without Inofolic®

Inofolic®

Gonadotropins; Folic Acid

Fabienne DELAY, PH

The original mechanism of action of myo-inositol and preliminary results available in the literature on its use in IVF suggest its value as adjuvant gonadotropin therapy to reduce the risk of OHSS in PCOS patients.

The aim of the study is to demonstrate that administration of myo-inositol decreases the incidence of ovarian hyperstimulation syndrome (OHSS) in high-risk infertile with PCOS supported in IVF patients.

Use of Myo-inositol as Adjuvant Therapy in Patients With Polycystic Ovary Syndrome (PCOS) in Vitro Fertilization (IVF)

Centre Hospitalier Departemental Vendee

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Surgical Ovarian Drilling Versus Hormonal Treatment for Infertility Associated to PolyCystic Ovaries Syndrome (PCOS)	NCT00378729	Polycystic Ovar...	Metformin and F... Ovarian drillin...	18 Years - 36 Years	Assistance Publique - Hôpitaux de Paris
Surgical Ovarian Drilling Versus Hormonal Treatment for Infertility Associated to PolyCystic Ovaries Syndrome (PCOS)	NCT00378729	Polycystic Ovar...	Metformin and F... Ovarian drillin...	18 Years - 36 Years	Assistance Publique - Hôpitaux de Paris
Use of Myo-inositol as Adjuvant Therapy in Patients With Polycystic Ovary Syndrome (PCOS) in Vitro Fertilization (IVF)	NCT02221154	Polycystic Ovar...	Inofolic® Gonadotropins; ...	18 Years - 38 Years	Centre Hospitalier Departemental Vendee
Surgical Ovarian Drilling Versus Hormonal Treatment for Infertility Associated to PolyCystic Ovaries Syndrome (PCOS)	NCT00378729	Polycystic Ovar...	Metformin and F... Ovarian drillin...	18 Years - 36 Years	Assistance Publique - Hôpitaux de Paris
Use of Myo-inositol as Adjuvant Therapy in Patients With Polycystic Ovary Syndrome (PCOS) in Vitro Fertilization (IVF)	NCT02221154	Polycystic Ovar...	Inofolic® Gonadotropins; ...	18 Years - 38 Years	Centre Hospitalier Departemental Vendee

Spots Global Cancer Trial Database for ovarian hyperstimulation