Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Symptoms and General Pathology

Breast Neoplasms

Amenorrhea

Menstruation Disturbances

Pascal PIGNY, MD,PhD

Chemotherapy for cancer, due to its gonadotoxicity, can lead to impaired female fertility, resulting in the occurrence of transient or prolonged chemo-induced amenorrhea (CIA). According to recent data from the National Cancer Institute, 11.9% of women under the age of 40 diagnosed with cancer have been offered a fertility evaluation within five years of diagnosis. Predicting the risk and especially the duration of the CIA remains difficult. Known factors predicting a rapid return of menstruation are a young age at diagnosis, a low gonadotoxic treatment (absence of alkylating agents) and a high pre-chemotherapy blood level of AMH reflecting a large pool of growing follicles. A body mass index (BMI) ≥ 25 kg / m² could also be a positive predictor, but this remains debated.

The objective of this project is to assess the impact of metabolism and energy reserves, physical activity and the chronotype on the recovery of ovarian function in patients with breast cancer who have developed CIA

Women with a chemotherapy-induced (CIA) amenorrhea

Metabolism, Circadian Rhythms and Ovarian Function

Impact of Metabolic Status and Circadian Rhythms on Post-chemotherapy Ovarian Recovery in Women Treated for Breast Cancer

Study the association between the IL-6 blood levels (in pg/ml) at the end of chemotherapy and the menstrual period return state ( before or after 6 months)

Leptin concentration in ng/ml; insulin concentration in mUI/L; ghrelin concentrations in pg/ml

Physical activity score expressed in arbitrary units

chronotype score expressed in arbitrary units

weight and height will be combined to report BMI in kg/m2

Leptin concentration in ng/ml, Insulin concentration in mUI/L, Ghrelin concentration in pg/ml

weight and height assessed at 3 months will be combined to report BMI in kg/m2

insulin concentrations expressed in mUI/L

ghrelin concentrations expressed in pg/ml

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Metabolism, Circadian Rhythms and Ovarian Function	NCT05007834	Chemotherapy-In...		25 Years - 35 Years	University Hospital, Lille
Metabolism, Circadian Rhythms and Ovarian Function	NCT05007834	Chemotherapy-In...		25 Years - 35 Years	University Hospital, Lille

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