Spots Global Cancer Trial Database for pathological complete response

Every month we try and update this database with for pathological complete response cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
THeragnostic Utilities for Neoplastic DisEases of the Rectum by MRI Guided Radiotherapy	NCT04815694	Neoadjuvant Che... Locally Advance... Pathological Co...	RT Dose escalat...	18 Years -	Fondazione Policlinico Universitario Agostino Gemelli IRCCS
The Efficacy and Safety of De-escalated Postoperative Radiotherapy in Locally Advanced HNSCC With pCR/MPR	NCT05854823	Head and Neck S...	dose-reduced ra...	18 Years - 70 Years	Fifth Affiliated Hospital, Sun Yat-Sen University
Neoadjuvant Bevacizumab, Capecitabine and Radiation Therapy With or Without Oxaliplatin Locally Advanced Rectal Cancer	NCT00828672	Locally Advance...	Oxaliplatin Bevacizumab Capecitabine radiotherapy	18 Years -	Universitaire Ziekenhuizen KU Leuven
Pathological Complete Response Rate in Locally Advanced Breast Cancer With FEC, EC-T, or TC as Neoadjuvant Chemotherapy	NCT03349177	Breast Cancer Pathological Co... Neoadjuvant Che...	Epirubicin Fluorouracil Docetaxel Cyclophosphamid...	18 Years - 70 Years	Shandong Cancer Hospital and Institute
Fasting Mimicking Diet Program to ImpRovE ChemoTherapy in Hormone Receptor Postive (HR+), HER2- Breast Cancer	NCT05503108	Fasting Mimicki... HER2-negative B... Hormone Recepto... Pathological Co... Objective Respo... Neoadjuvant Che...	Fasting Mimicki...	18 Years -	Leiden University Medical Center
The Efficacy and Safety of De-escalated Postoperative Radiotherapy in Locally Advanced HNSCC With pCR/MPR	NCT05854823	Head and Neck S...	dose-reduced ra...	18 Years - 70 Years	Fifth Affiliated Hospital, Sun Yat-Sen University
Neoadjuvant Chemoradiotherapy vs. Chemotherapy With Radical Gastrectomy and Adjuvant Chemotherapy for Advanced Gastric Cancer	NCT01815853	Gastric Cancer	Neoadjuvant Che... Neoadjuvant Che... R0 D2 Gastrecto... Adjuvant Chemot...	18 Years - 75 Years	Sun Yat-sen University
Preoperative Concurrent Chemotherapy and Intensity Modulated Radiotherapy (IMRT) in Locally Advanced Rectal Cancer	NCT01340508	Rectal Cancers.	Intensity Modul...	21 Years - 90 Years	National University Hospital, Singapore
Deep Learning Model Predicts Pathological Complete Response of Lung Cancer Following Neoadjuvant Immunochemotherapy	NCT06285058	Deep Learning M... Pathological Co... Non-small Cell ... Neoadjuvant Che...	No intervention...	18 Years - 80 Years	Wuhan Union Hospital, China
Deep Learning Model Predicts Pathological Complete Response of Lung Cancer Following Neoadjuvant Immunochemotherapy	NCT06285058	Deep Learning M... Pathological Co... Non-small Cell ... Neoadjuvant Che...	No intervention...	18 Years - 80 Years	Wuhan Union Hospital, China
Patient-reported Outcomes in Preoperative Immunochemotherapy/Radiotherapy-treated Esophageal Cancer Patients	NCT05596890	Esophageal Squa... Patient-reporte... Immunotherapy	Paclitaxel-albu... Cisplatin Carboplatin Tislelizumab VMAT or IMRT Esophagectomy	18 Years - 75 Years	Guangdong Provincial People's Hospital
Neoadjuvant Chemoradiotherapy vs. Chemotherapy With Radical Gastrectomy and Adjuvant Chemotherapy for Advanced Gastric Cancer	NCT01815853	Gastric Cancer	Neoadjuvant Che... Neoadjuvant Che... R0 D2 Gastrecto... Adjuvant Chemot...	18 Years - 75 Years	Sun Yat-sen University
Preoperative Concurrent Chemotherapy and Intensity Modulated Radiotherapy (IMRT) in Locally Advanced Rectal Cancer	NCT01340508	Rectal Cancers.	Intensity Modul...	21 Years - 90 Years	National University Hospital, Singapore
A Cohort of Predictive Factor of Pathologic Complete Response After Preoperative Neoadjuvant in Rectum Cancer	NCT04443985	Rectum Cancer		18 Years -	Mahidol University
Assessment of Breast Cancer Response to Neoadjuvant Anthracycline-based Chemotherapy by FDG-PET and Molecular Markers	NCT02600442	Breast Neoplasm... Breast Cancer	non interventio...	-	Assistance Publique - Hôpitaux de Paris
Patient-reported Outcomes in Preoperative Immunochemotherapy/Radiotherapy-treated Esophageal Cancer Patients	NCT05596890	Esophageal Squa... Patient-reporte... Immunotherapy	Paclitaxel-albu... Cisplatin Carboplatin Tislelizumab VMAT or IMRT Esophagectomy	18 Years - 75 Years	Guangdong Provincial People's Hospital
Omission of Breast Surgery for Breast Cancer Patients With pCR on MRI and Vacuum-assisted Biopsy After NST (OPTIMIST)	NCT05505357	Breast Cancer I...	Breast surgery ...	20 Years -	Seoul National University Hospital
Omission of ALND in Breast Cancer Patients With Axillary pCR	NCT05939830	Axillary Lymph ... Pathological Co... Neoadjuvant Sys... Breast Cancer Axillary Lymph	Stained region ... Regional lymph ...	18 Years - 70 Years	The First Affiliated Hospital with Nanjing Medical University
Neoadjuvant Bevacizumab, Capecitabine and Radiation Therapy With or Without Oxaliplatin Locally Advanced Rectal Cancer	NCT00828672	Locally Advance...	Oxaliplatin Bevacizumab Capecitabine radiotherapy	18 Years -	Universitaire Ziekenhuizen KU Leuven
A Trial of High Intensity Versus Low Intensity Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer	NCT01064999	Rectal Cancer	Oxaliplatin Capecitabine Radiotherapy Surgery	18 Years - 75 Years	Fudan University
Evaluating 6-months of HER2-targeted Therapy in Patients With HER2 Positive Early-stage Breast Cancer That Achieve a Pathological Complete Response to Neoadjuvant Systemic Therapy	NCT04928261	Breast Cancer	Trastuzumab	18 Years -	Ottawa Hospital Research Institute
Sequential Neo-adjuvant Chemotherapy Followed by Capecitabine Vs. Conventional Adjuvant Chemotherapy in Breast Cancer	NCT03011060	Breast Neoplasm...	Neo-adjuvant Ch... Capecitabine	18 Years - 70 Years	The First Hospital of Jilin University
RECTAL BOOST Study	NCT01951521	Rectal Cancer	Boost	18 Years -	UMC Utrecht
Diagnosis of Pathological Complete Response by Vacuum-assisted Biopsy After Neoadjuvant Chemotherapy in Breast Cancer	NCT02948764	Breast Neoplasm...	Vacuum-Assisted...	18 Years -	Heidelberg University
Cisplatin-monotherapy in the Treatment of BRCA1 Positive Breast Cancer Patients in Poland	NCT01630226	BRCA1 Mutation Breast Cancer I...	Neoadjuvant Cis...	20 Years - 70 Years	Pomeranian Medical University Szczecin
Diagnosis of Pathological Complete Response by Vacuum-assisted Biopsy After Neoadjuvant Chemotherapy in Breast Cancer	NCT02948764	Breast Neoplasm...	Vacuum-Assisted...	18 Years -	Heidelberg University
DIetary REstriction as an Adjunct to Neoadjuvant ChemoTherapy for HER2 Negative Breast Cancer	NCT02126449	Fasting Mimicki... Breast Cancer Neoadjuvant Che... Pathological Co...	Fasting mimicki...	18 Years - 70 Years	Leiden University Medical Center
Evaluation of the Accuracy of Percutaneous Biopsy by Vacuum-assisted Biopsy (VAB) to Assess Pathological Complete Response in Patients With Clinical and Radiological Complete Response After Neoadjuvant Chemotherapy (NeoVAB)	NCT03876951	Vacuum-assisted...	Vacuum-assisted...	18 Years -	Centre Georges Francois Leclerc
Evaluating 6-months of HER2-targeted Therapy in Patients With HER2 Positive Early-stage Breast Cancer That Achieve a Pathological Complete Response to Neoadjuvant Systemic Therapy	NCT04928261	Breast Cancer	Trastuzumab	18 Years -	Ottawa Hospital Research Institute
Neoadjuvant Bevacizumab, Capecitabine and Radiation Therapy With or Without Oxaliplatin Locally Advanced Rectal Cancer	NCT00828672	Locally Advance...	Oxaliplatin Bevacizumab Capecitabine radiotherapy	18 Years -	Universitaire Ziekenhuizen KU Leuven
Monitoring Response to NAC and Prediction of pCR in Breast Cancer Patients Using Optical Imaging	NCT04767659	Breast Cancer F... Chemotherapy Ef...	MAMMOT2	18 Years -	IRCCS San Raffaele
Neoadjuvant Nivolumab for Upper Tract Urothelial Carcinoma	NCT05160285	Upper Urinary T...	Nivolumab 100 M...	20 Years - 85 Years	Chang Gung Memorial Hospital
Deep Learning Model Predicts Pathological Complete Response of Lung Cancer Following Neoadjuvant Immunochemotherapy	NCT06285058	Deep Learning M... Pathological Co... Non-small Cell ... Neoadjuvant Che...	No intervention...	18 Years - 80 Years	Wuhan Union Hospital, China
Fasting Mimicking Diet Program to ImpRovE ChemoTherapy in Hormone Receptor Postive (HR+), HER2- Breast Cancer	NCT05503108	Fasting Mimicki... HER2-negative B... Hormone Recepto... Pathological Co... Objective Respo... Neoadjuvant Che...	Fasting Mimicki...	18 Years -	Leiden University Medical Center
Cisplatin-monotherapy in the Treatment of BRCA1 Positive Breast Cancer Patients in Poland	NCT01630226	BRCA1 Mutation Breast Cancer I...	Neoadjuvant Cis...	20 Years - 70 Years	Pomeranian Medical University Szczecin
Effect of Concurrent Capecitabine-based Long-term Radiotherapy Followed by XELOX Plus TME in Patients With High Risk Rectal Cancer: a Multi-centers, Randomized Controlled, Open-Label Trial	NCT03038256	Rectal Cancer Pathological Co... Disease Free Su...	concurrent cape... concurrent cape...	18 Years - 75 Years	Peking University People's Hospital
Assessment of Breast Cancer Response to Neoadjuvant Anthracycline-based Chemotherapy by FDG-PET and Molecular Markers	NCT02600442	Breast Neoplasm... Breast Cancer	non interventio...	-	Assistance Publique - Hôpitaux de Paris
Efficacy and Safety of Combinition of Camrelizumab in Second-line Neoadjuvant Chemotherapy and Adjuvant Therapy	NCT04848454	HER2-negative B... Neoadjuvant The... Pathological Co... Immunotherapy Vinorelbine Cisplatin	Camrelizumab wi...	18 Years - 70 Years	Peking University First Hospital
Neoadjuvant Cadonilimab Combined With Anlotinib in Locally Advanced Resectable Esophageal Squamous Cell Carcinoma	NCT06426797	Locally Advance...	Cadonilimab plu...	18 Years -	Peking University People's Hospital
DIetary REstriction as an Adjunct to Neoadjuvant ChemoTherapy for HER2 Negative Breast Cancer	NCT02126449	Fasting Mimicki... Breast Cancer Neoadjuvant Che... Pathological Co...	Fasting mimicki...	18 Years - 70 Years	Leiden University Medical Center

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