Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Blood and Lymph Conditions

Breast Neoplasms

Leukopenia

Breast Diseases

Skin Diseases

Cytopenia

Hematologic Diseases

Leukocyte Disorders

Start to take the powder of Chinese herb-LCH1 3g\*BID just after the 1st chemotherapy, and Stop 2-3 weeks after the final cycle of chemotherapy.

Chinese medical treatment-LCH1

Start to take the powder of Placebo 3g\*BID just after the 1st chemotherapy, and stop 2-3 weeks after the final chemotherapy.

Placebo

Lin Jui-Shan, MD., PhD.

Jui-shan Lin, MD., PhD.

Hwei-Chung Wang, MD.

Yi-Chang Su, MD., PhD.

This is a two-year double blind, placebo-controlled, and randomized clinical trial, which is aimed to evaluate the effects of Chinese medical treatment on leucopenia after chemotherapy in breast cancer patients.

The study will be conducted in the Department of Breast Surgery in China Medical University Hospital, Taichung. One hundred newly diagnosed breast cancer patient (age ≧18, Stage I, II, IIIa) will be included. After the diagnosis, the patients will undergo operation. Then, each patient will receive one of the following protocol of chemotherapy according to her pathology report and overall evaluation: "FEC\*6", "FEC\*4+Taxotere\*4", and "FEC\*3+Taxotere\*3".

Every participator will start to take the powder of Chinese herb-LCH1 after her receiving first time of chemotherapy until she receives the next cycle.(While receiving "FEC", it will be 3 weeks. While receiving "Taxotere", it will be 4 weeks).

Just before receiving the next cycle of chemotherapy, the blood of the participator will be sampled to check her CBC, GOT/GPT, BUN/Cr and tumor maker.

The investigators also adopt the body constitution questionnaire (BCQ) to evaluate the Chinese medical constitutional status, the EORTC QLQ-C30, EORTC QLQ-BR23, and Karnofsky score to evaluate the quality of life, and to evaluate the adverse effects of the adjuvant chemotherapy with the NCI-CTCAE Version 3.0.

Each participator will take the powder of Chinese herb-LCH1 from her first chemotherapy till 3 weeks after the last cycle of chemotherapy. Over all, it will take about 18 weeks (FEC\*6) to 28 weeks (FEC\*4+Taxotere\*4) to complete the treatment.

This study will also investigate the influence of the chemotherapy on the Chinese medical constitutional status, and in order to provide the basis for the complementary treatment for the breast cancer by adjusting and balancing the constitutional status of the patients.

Evaluation of the Effects of Chinese Medical Treatment on Leucopenia After Chemotherapy in Breast Cancer Patients

All the patients will be stratified according to her chemotherapy protocol : "FEC\*6", "FEC\*4+Taxotere\*4", and "FEC\*3+Taxotere\*3".

The WBC will be checked before receiving each cycle of chemotherapy and at the follow up 3 weeks after the completion of chemotherapy.

If the participator receives the protocol "FEC\*6", her WBC will be checked every 3 weeks for 7 times. It will takes 21 weeks to get the values of WBC at 7 different time point. And it will takes 31 weeks and 24 weeks for participators receive the protocol "FEC\*4+Taxotere\*4" and "FEC\*3+Taxotere\*3", respectively.

All the patients will be stratified according to her chemotherapy protocol : "FEC\*6", "FEC\*4+Taxotere\*4", and "FEC\*3+Taxotere\*3".

Score of EORTC QLQ-C30 will be evaluated before receiving each cycle of chemotherapy and at the follow up 3 weeks after the completion of chemotherapy.

If the participator receives the protocol "FEC\*6", her score will be checked every 3 weeks for 7 times. It will takes 21 weeks to get the score at 7 different time point. And it will takes 31 weeks and 24 weeks for participators receive the protocol "FEC\*4+Taxotere\*4" and "FEC\*3+Taxotere\*3", respectively.

Department of Health, Executive Yuan, R.O.C. (Taiwan)

China Medical University Hospital

Director of Surgery Department

Behaviors and Mental Disorders

Infections

Respiratory Tract (Lung and Bronchial) Diseases

Symptoms and General Pathology

Anxiety Disorders

COVID-19

Pain

Pneumonia

Pneumonia, Viral

Communicable Diseases

Respiratory Tract Infections

Virus Diseases

Coronavirus Infections

Coronaviridae Infections

Nidovirales Infections

RNA Virus Infections

Lung Diseases

Respiratory Tract Diseases

The patients in the experimental group were listened to music.

Listening Music

The control group was not listened to music.

Not Listening Music

Rukuye AYLAZ

Introduction: This study has been conducted to determine the effect of music on pain and anxiety levels in patients receiving chemotherapy during COVID-19.

Methods: The research has been carried out in a real trial model with adult patients receiving chemotherapy. The sample of the study is consisted of 92 patients (45 in the experimental group and 47 for the control group). The data have been collected by the researcher with Google Forms (using State and Transient Anxiety Inventory and Visual Analog Skala) between March 2020 and July 2020, through the links sent to the phones of participants on the day they received chemotherapy.

Results: The mean scores obtained from the post-test STAI (53.11±4.77) and VAS (3.44±2.53) scales in the experimental group have been determined to statistically significantly decrease when compared to the pre-test measurement data (STAI:54.26±4.26; VAS:4.22±2.41) (p\<0.05). No statistically significant difference has been determined between pre-test and post-test mean scores of the patients in the control group.

Conclusion: It has been observed that music applications reduce the pain and anxiety levels of patients receiving chemotherapy during the COVID-19 process. It can be recommended to use music applications in the management of pain and anxiety symptoms.

The Effect of Music on Pain and Anxiety in Patients Receiving Chemotherapy During COVID-19

The data have been collected by the researcher with Google Forms (using State and Transient Anxiety Inventory and Visual Analog Skala).The posttest was administered 1 hour after the pretest.

Inonu University

Lecturer

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Evaluation of the Effects of Chinese Medical Treatment on Leucopenia After Chemotherapy in Breast Cancer Patients	NCT01359501	Leucopenia Breast Cancer	Chinese medical... Placebo	18 Years -	China Medical University Hospital
Evaluation of the Effects of Chinese Medical Treatment on Leucopenia After Chemotherapy in Breast Cancer Patients	NCT01359501	Leucopenia Breast Cancer	Chinese medical... Placebo	18 Years -	China Medical University Hospital
The Effect of Music on Pain and Anxiety in Patients Receiving Chemotherapy During COVID-19	NCT05334641	Cancer Chemotherapy	Listening Music Not Listening M...	18 Years -	Inonu University
The Effect of Music on Pain and Anxiety in Patients Receiving Chemotherapy During COVID-19	NCT05334641	Cancer Chemotherapy	Listening Music Not Listening M...	18 Years -	Inonu University
Evaluation of the Effects of Chinese Medical Treatment on Leucopenia After Chemotherapy in Breast Cancer Patients	NCT01359501	Leucopenia Breast Cancer	Chinese medical... Placebo	18 Years -	China Medical University Hospital

Spots Global Cancer Trial Database for patients receiving chemotherapy