Neoplasms

All Conditions

Rare Diseases

Rhabdomyosarcoma

Myosarcoma

Neoplasms, Connective and Soft Tissue

Neoplasms by Histologic Type

Sarcoma

Soft Tissue Sarcoma

Once per day, 5 days a week for a total of 4 to 6 weeks.

Proton Beam Radiation

Torunn Yock, MD

Karen Marcus, MD

Anita Mahajan, MD

The main purpose of this study is to see if using proton beam radiation therapy instead of photon beam radiation therapy can reduce side effects from radiation treatment for rhabdomyosarcoma. Photon beam radiation is the standard type of radiation for treating most rhabdomyosarcoma and many other types of cancer. Photon beam radiation enters the body and passes through healthy tissue, encounters the tumor, then leaves the body through healthy tissue. A beam of proton radiation enters the body and passes through healthy tissue, encounters tumor, but then stops. This means that less healthy tissue is affected by proton beam radiation than by photon beam radiation.

* A special device is made for each participant to help them hold still during the treatment. This may be in the form of a mask or a custom made foam cradle depending on the area to be treated.
* Radiation treatments will be given once per day, 5 days a week for a total of 4 to 6 weeks, depending upon how much total dose the tumor requires.
* Participants will be seen once per week by their radiation doctor to monitor health and record any side effects from treatment.
* After the radiation treatments are completed, participants will be required to undergo further tests and evaluations for several years following treatment.

Proton RT for the Treatment of Pediatric Rhabdomyosarcoma

A Phase II Trial of Proton RT for the Treatment of Pediatric Rhabdomyosarcoma

Frequency and severity of late complications from irradiation using proton beam therapy in place of conventional photon beam therapy in pediatric patients with pediatric rhabdomyosarcomas.

Frequency and severity of acute side effects from irradiation using proton beam therapy in this patient population.

Comparison of Dose distribution to tumor and surrounding normal structures using DVH's generated from the proton plan used to treat the patient and the photon plan generated for comparison purposes.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Proton RT for the Treatment of Pediatric Rhabdomyosarcoma	NCT00592592	Rhabdomyosarcom...	Proton Beam Rad...	- 21 Years	Massachusetts General Hospital
Proton RT for the Treatment of Pediatric Rhabdomyosarcoma	NCT00592592	Rhabdomyosarcom...	Proton Beam Rad...	- 21 Years	Massachusetts General Hospital

Spots Global Cancer Trial Database for pediatric rhabdomyosarcoma