Digestive System Diseases

All Conditions

Liver Diseases

Gastrointestinal Diseases

Antineoplastic Agents

All Drugs and Chemicals

Hematinics

Irinotecan

Liver Extracts

Topoisomerase I Inhibitors

Enzyme Inhibitors

Drugs used in chemotherapy us different ways to stop tumor cells from dividing so they stop growing or die. Irinotecan may be effective in treating patients with refractory solid tumors and liver dysfunction.

Irinotecan in Treating Patients With Refractory Solid Tumors and Liver Dysfunction

Pfizer

Neoplasms

Heart and Blood Diseases

Blood and Lymph Conditions

Immune System Diseases

Rare Diseases

Multiple Myeloma

Neoplasms, Plasma Cell

Neoplasms by Histologic Type

Hemostatic Disorders

Blood Coagulation Disorders

Vascular Diseases

Paraproteinemias

Blood Protein Disorders

Hematologic Diseases

Hemorrhagic Disorders

Lymphoproliferative Disorders

Immunoproliferative Disorders

Investigational drug

The primary goal of the study is to determine the best dose of an investigational drug to give to patients with multiple myeloma and to evaluate the investigational drug's effectiveness as a treatment for multiple myeloma.

Study of the Safety and Efficacy of an Investigational Drug in Adult Patients With Multiple Myeloma

Respiratory Tract (Lung and Bronchial) Diseases

Lung Neoplasms

Carcinoma, Non-Small-Cell Lung

Carcinoma

Carcinoma, Bronchogenic

Bronchial Neoplasms

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

The primary goal of the study is to evaluate an investigational drug's effectiveness as a treatment for Non small-cell lung cancer (NSCLC)

Study of the Efficacy of an Investigational Drug in Adult Patients With Non Small-Cell Lung Cancer (NSCLC)

Symptoms and General Pathology

Colorectal Neoplasms

Diarrhea

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Colonic Diseases

Intestinal Diseases

Rectal Diseases

Signs and Symptoms, Digestive

Micronutrients

Vitamins

Leucovorin

Fluorouracil

Antimetabolites

Immunosuppressive Agents

Immunologic Factors

Antidotes

Protective Agents

Folic Acid

Vitamin B Complex

Trace Elements

Folate

Vitamin B9

5-fluorouracil

The study will combine a new investigational drug with standard anti-cancer drugs for the treatment of advanced colorectal cancer. The standard and approved treatment for colorectal cancer is to undergo chemotherapy with a combination of irinotecan (also known as CPT-11, Camptosar), 5-fluorouracil (also known as 5-FU), and leucovorin (also known as LV). This is known as the triple therapy. One of the major side effects of CPT-11/5-FU/LV chemotherapy treatment is diarrhea. The purpose of this research study is to see whether adding this investigational drug to the standard treatment for advanced colorectal cancer can reduce the amount of diarrhea a patient experiences. This study will also determine if adding the investigational drug to triple therapy has a positive effect on tumors.

A Trial of an Investigational Drug for the Prevention of Diarrhea Associated With Irinotecan/5FU/Leucovorin Chemotherapy in Previously Untreated Metastatic Colorectal Cancer

A Phase II, Randomized, Open-label, Controlled, Dose-elevation, Multicenter Trial of an Investigational Drug for the Prevention of Diarrhea Associated With Irinotecan/5FU/Leucovorin Chemotherapy in Patients With Previously Untreated Metastatic Colorectal Cancer

Celgene Corporation

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Irinotecan in Treating Patients With Refractory Solid Tumors and Liver Dysfunction	NCT00037804	Unspecified Adu... Chemotherapy Liver Dysfuncti... Neoplasms, Soli...	Irinotecan	18 Years -	Pfizer
Study of the Safety and Efficacy of an Investigational Drug in Adult Patients With Multiple Myeloma	NCT00036140	Multiple Myelom...	Investigational...	18 Years -	Pfizer
Study of the Efficacy of an Investigational Drug in Adult Patients With Non Small-Cell Lung Cancer (NSCLC)	NCT00034957	Carcinoma, Non-... Lung Neoplasms	Investigational...	18 Years -	Pfizer
A Trial of an Investigational Drug for the Prevention of Diarrhea Associated With Irinotecan/5FU/Leucovorin Chemotherapy in Previously Untreated Metastatic Colorectal Cancer	NCT00040391	Colorectal Neop... Diarrhea	Investigational... Irinotecan 5-fluorouracil Leucovorin	18 Years -	Celgene Corporation
Study of the Safety and Efficacy of an Investigational Drug in Adult Patients With Multiple Myeloma	NCT00036140	Multiple Myelom...	Investigational...	18 Years -	Pfizer
Irinotecan in Treating Patients With Refractory Solid Tumors and Liver Dysfunction	NCT00037804	Unspecified Adu... Chemotherapy Liver Dysfuncti... Neoplasms, Soli...	Irinotecan	18 Years -	Pfizer
Study of the Safety and Efficacy of an Investigational Drug in Adult Patients With Multiple Myeloma	NCT00036140	Multiple Myelom...	Investigational...	18 Years -	Pfizer
Irinotecan in Treating Patients With Refractory Solid Tumors and Liver Dysfunction	NCT00037804	Unspecified Adu... Chemotherapy Liver Dysfuncti... Neoplasms, Soli...	Irinotecan	18 Years -	Pfizer

Spots Global Cancer Trial Database for pharmacia

Every month we try and update this database with for pharmacia cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for pharmacia

Every month we try and update this database with for pharmacia cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for pharmacia cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.