Neoplasms

Digestive System Diseases

Gland and Hormone Related Diseases

All Conditions

Nervous System Diseases

Symptoms and General Pathology

Rare Diseases

Pancreatic Neoplasms

Sarcopenia

Atrophy

Muscular Atrophy

Neuromuscular Manifestations

Neurologic Manifestations

Pathological Conditions, Anatomical

Pancreatic Cancer

4-week trimodal prehabilitation program: Exercise, nutritional supplementation, and psychological support

Prehabilitation program

perioperative immunonutrition by ORAL IMPACT

Oral Impact

Mehdi ELAMRANI, MD

Major digestive surgery is associated with a significant rate of postoperative complications. To improve postoperative outcome, efforts are focused on postoperative course leading to the concept of rehabilitation. However, the rehabilitation concept does not allow to improve muscular and functional reserves at the time of surgery. Sarcopenia is a condition characterized by loss of skeletal muscle mass and function. Also, the prevalence of sarcopenia in patients with cancer is high and has a prevalence of around 25% in patients with pancreatic cancer, with a considerable impact on postoperative and survival outcomes.

The hypothesis is the preoperative management of sarcopenia by a rehabilitation program could improve patients' operative outcomes by reducing the rate of postoperative complications.

Preoperative Prehabilitation for Sarcopenic Patients Prior to Pancreatic Surgery for Cancer

Prehabilitaion Program for Sarcopenic Patients Prior to Pancreaticoduodenectomy for Periampullary Malignant Tumors

Pancreatic fistula as defined by the International Study Group of pancreatic Fistula (ISGPF)

Grade \> IIIa (Clavien-Dindo classification)

self questionnaire to measure opinion with respect of rehabilitation program

EVAN-G general patient satisfaction questionnaire consisting of 26 items divided into 6 sub-sections scoring on a scale from 0 to 100. It is designed to report perioperative problems.

French self-administered instrument for measuring hospitalized patients' satisfaction based on the patient's point of view. QSH contained 45 items describing 9 dimensions, leading to 2 composite scores (staff and structure index)

The QLQ-C30 is a questionnaire developed to assess the quality of life of cancer patients. The questionnaire includes one global health status/QoL scale, five functional scales and three symptom scale. Each scale is scored from 0 to 100. A high score on a scale indicate a good outcome for the dimension of QoL.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Preoperative Prehabilitation for Sarcopenic Patients Prior to Pancreatic Surgery for Cancer	NCT04469504	Sarcopenia Pancreatic Canc...	Prehabilitation... Oral Impact	18 Years -	University Hospital, Lille
Preoperative Prehabilitation for Sarcopenic Patients Prior to Pancreatic Surgery for Cancer	NCT04469504	Sarcopenia Pancreatic Canc...	Prehabilitation... Oral Impact	18 Years -	University Hospital, Lille
Preoperative Prehabilitation for Sarcopenic Patients Prior to Pancreatic Surgery for Cancer	NCT04469504	Sarcopenia Pancreatic Canc...	Prehabilitation... Oral Impact	18 Years -	University Hospital, Lille

Spots Global Cancer Trial Database for prehabilitaion