Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Breast Neoplasms

Breast Diseases

Skin Diseases

Standard Systemic Therapy only group (no primary surgery)

Primary breast surgery before systemic therapy

Primary surgery

Atilla Soran, MD, MPH

Primary treatments for metastatic breast cancer are chemotherapy and radiation therapy, and surgery is reserved for tumor related complications such as bleeding. Retrospective studies showed that surgical removal of the primary tumor improves survival of patients with metastatic breast cancer at diagnosis. We hypothesis and testing that surgical removal of the primary tumor will lead to an improvement of overall survival

This is a randomised, controled clinical trial. Our aim is to observe whether primary surgery improves survival in metastatic breast cancer. Women who have metastatic breast cancer at the initial diagnosis will be included in the study. There will be two study arms: primary surgery and systemic chemotherapy groups.

In the primary surgery group patients will have adjuvant therapies after they had the proper surgery. In the systemic chemotherapy group patients will be followed after their initial therapy and will have surgery only if they have locoregional problems (such as wide necrosis or bleeding, etc). During the follow-up period, patients will be seen in every 6 months.

Local Surgery for Metastatic Breast Cancer

The Effect of Primary Surgical Treatment on Survival in Patients With Metastatic Breast Cancer at Diagnosis

Istanbul University

Abant Izzet Baysal University

Marmara University

Federation of Breast Diseases Societies

Respiratory Tract (Lung and Bronchial) Diseases

Behaviors and Mental Disorders

Lung Neoplasms

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Quality of Life

Either 3 fractions of 20 Gray or 5 fractions of 12 Gy

stereotactic radiotherapy

an anatomical surgical resection with lymph node dissection

primary surgery

The standard treatment for an early stage I lung cancer is surgery. However, surgery can be associated with complications and long-term impairment of the quality of life of patients. Stereotactic radiotherapy (SRT) is a outpatient technique which allows for local control rates that are comparable to those achieved using surgery. In this study, patients with stage IA non-small cell lung cancer will be randomized to either surgery or SRT in order to study the local and regional tumor control, quality of life and treatment costs at 2- and 5-years.

Trial of Either Surgery or Stereotactic Radiotherapy for Early Stage (IA) Lung Cancer

A Randomized Clinical Trial of Surgery Versus Radiosurgery (Stereotactic Radiotherapy) in Patients With Stage IA NSCLC Who Are Fit to Undergo Primary Resection

ZonMw: The Netherlands Organisation for Health Research and Development

Amsterdam UMC, location VUmc

Principal investigator

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Local Surgery for Metastatic Breast Cancer	NCT00557986	Breast Cancer	Primary surgery	-	Federation of Breast Diseases Societies
Local Surgery for Metastatic Breast Cancer	NCT00557986	Breast Cancer	Primary surgery	-	Federation of Breast Diseases Societies
Trial of Either Surgery or Stereotactic Radiotherapy for Early Stage (IA) Lung Cancer	NCT00687986	Lung Cancer	stereotactic ra... primary surgery	18 Years -	Amsterdam UMC, location VUmc
Trial of Either Surgery or Stereotactic Radiotherapy for Early Stage (IA) Lung Cancer	NCT00687986	Lung Cancer	stereotactic ra... primary surgery	18 Years -	Amsterdam UMC, location VUmc

Spots Global Cancer Trial Database for primary surgery