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Colorectal Neoplasms

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Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Patients in this observational study will have undergone CT scan as routine work up prior to resection of elective colorectal cancer.

Psoas muscle density will be measured (in Hounsfield units from CT images) at lumbar vertebral level L3.

Jonathan N Lund, MD

James EM Blackwell, PhD BMBS

Colorectal cancer (CRC) is the 3rd most common cancer worldwide. In the UK, CRC is the 4th most common cancer accounting for 12% of cancers diagnosed each year with approximately 41,300 new cases diagnosed in 2014. Surgery remains the only treatment option that can reliably achieve cure from colorectal cancer and thus nearly 20,000 major bowel resections are performed for this yearly in the UK. Surgery for these cancers however carries risk of major complications and potentially death. Selecting appropriate patients for surgery remains a challenge to cancer teams.

Risk factors exist for complications after surgery for CRC, many of which can be assessed and discussed with the patient prior to surgery, so that any decision to operate is with fully informed consent from the patient. Increasing attention is being paid to a patient's frailty or fitness as one of these risk factors. Our centre has previously shown that measuring the cross-sectional area of the psoas muscle (a large muscle near the spine) from preoperative imaging could predict major complications in colorectal cancer patients (Jones 2015), however specialist software and patient height is required to make this calculation. More recently we have demonstrated that the measurement of the psoas muscle density on preoperative imaging (i.e. routine CT scans that all patients have before surgery to plan treatment), may potentially be useful to predict which patients are at most risk of a major complication (Herrod 2019). If this finding holds true when tested on a larger scale, it could be used to help surgical teams make the decision on whether to offer surgical resection, what kind of operations to perform, how to best support individuals undergoing operation and to ensure that the patient has the most information available to decide what risk they are at by having major surgery.

Psoas Density in Colorectal Cancer

Evaluating the Association Between Psoas Density Measurement on Preoperative CT Imaging and Postoperative Outcomes

Recorded post operative complications requiring intervention during post operative stay until initial discharge from hospital.

Recorded post operative complications (including re-operation or recurrence) until discharge from surgical clinic or date of record review.

University of Nottingham

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Psoas Density in Colorectal Cancer	NCT04198025	Cancer of Colon		18 Years -	University of Nottingham
Psoas Density in Colorectal Cancer	NCT04198025	Cancer of Colon		18 Years -	University of Nottingham

Spots Global Cancer Trial Database for psoas muscle density