Neoplasms

All Conditions

Diseases and Abnormalities at or Before Birth

Skin and Connective Tissue Diseases

Hemangioma, Capillary

Port-Wine Stain

Hemangioma

Congenital Abnormalities

Skin Abnormalities

Skin Diseases

Neoplasms, Vascular Tissue

Neoplasms by Histologic Type

Antineoplastic Agents

All Drugs and Chemicals

Angiogenesis Inhibitors

Growth Inhibitors

Topical Antiangiogenic

Pulsed Dye Laser

John S Nelson, M.D,PhD

The researcher want to improve port wine stain (PWS) therapeutic outcome in response to laser therapy. The researcher want to determine whether the combined use of pulsed dye laser (PDL) therapy and topical tacrolimus or pimecrolimus will improve PWS therapeutic outcome.

Both topical agents inhibit nuclear factor of activated T-cells (NFAT) which blocks the calcineurin/NFAT pathway inhibiting endothelial cell proliferation and angiogenesis, which could be very useful in preventing PWS recanalization.

The combined use of PDL to induce PWS blood vessel injury, and topical antiangiogenic agents to prevent PWS blood vessel angiogenesis and recanalization after laser therapy, will improve PWS lesion blanching.

Combined Use of Pulsed Dye Laser and Topical Antiangiogenic Agents for Treatment of Port Wine Stain Birthmarks

Beckman Laser Institute University of California Irvine

University of California, Irvine

J S Nelson, M.D., Ph.D.,Professor of Surgery and Biomedical Engineering

FLIR Systems, Boston, MA. This is a non invasive passive thermal imaging device with less than minimal risk to subjects and staff.

ThermoVision A20M Infrared Camera

Sclerolaser, Candela Corp., Wayland, MA. This laser is approved by the food and drug administration (FDA) for treating PWS lesions and will be used as labeled.

ScleroPLUS

3dMD, Atlanta, GA. Approved by the food and drug administration (FDA) for imaging patients and will be used as labeled.

3D Digital Camera

Gal Shafirstein, PhD

Lasers are being used to treat Port Wine Stains (PWS), but the laser doesn't always work. Only about 10% of PWS can be completely cleared. The research team believes that the investigators can improve the response of PWS to laser therapy by using a computer program that the principal investigator of this study (Dr. Shafirstein PhD) has developed. The purpose of this study is to test the validity of this computer program. Personalized Interactive Laser Therapy (PILT) could significantly improve clinical outcomes of laser treatment of PWS.

Personalized Interactive Laser Therapy of Port Wine Stain

Personalized Interactive Laser Therapy of Port Wine Stain - Study 2

6 subjects were enrolled but no data was ever collected due to early termination of the study due to the PI's relocation.

Arkansas Children's Hospital Research Institute

Children's University Medical Group

University of Arkansas

Overall

Age, Categorical

Sex: Female, Male

United States

Region of Enrollment

PI relocated and protocol was terminated, and no subject returned for treatment under protocol.

Dr. Gal Shafirstein

Laser Therapy

Average Laser Setting to be Used to Treat Port Wine Stains as Measured by Mathematical Calculations Based on Imaging and Temperature Analysis of Malformation.

Overall Study

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Combined Use of Pulsed Dye Laser and Topical Antiangiogenic Agents for Treatment of Port Wine Stain Birthmarks	NCT00969397	Port Wine Stain	Topical Antiang... Pulsed Dye Lase...	16 Years -	University of California, Irvine
Personalized Interactive Laser Therapy of Port Wine Stain	NCT00782483	Port Wine Stain	ThermoVision A2... ScleroPLUS 3D Digital Came...	3 Months - 17 Years	University of Arkansas

Spots Global Cancer Trial Database for pws

Every month we try and update this database with for pws cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for pws

Every month we try and update this database with for pws cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for pws cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.