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Esophagectomy with pyloric drainage procedure

Esophagectomy without pyloric drainage procedure

Ten questions regarding symptoms of reflux

Telephone Questionnaire

Reza J. Mehran, MD

The purpose of the current study is to assess the role of pyloric drainage procedure on altering the reflux effect on the quality of life in patients who underwent esophagectomy. Researchers hypothesize that the patients who underwent minimally invasive esophagectomies without pyloric drainage experience less reflux symptoms and therefore have a better quality of life.

Surgery is considered curative for patients with esophageal cancer. The minimally invasive approach was developed such that laparoscopy and thoracoscopy replace large abdominal and thoracic incisions. For both open and minimally invasive procedures, patients have many adjustments to overcome in order to regain quality of life that is within the norm. In a recent study on the health-related quality of life (HRQL) after curative surgical resection, symptoms of reflux was the only variable that worsened with statistical significance.

The study plan is to retrospectively compare two groups of patients: those who underwent esophagectomy with pyloric drainage procedure and those who did not. The study will be done using all MD Anderson patients who underwent minimally invasive esophagectomies, in which pyloroplasty and pyloromyotomy are not standard procedures. Clinically relevant data and demographic information will be collected retrospectively for the two groups including age, gender, Body Mass Index, level of anastomosis, and time elapsed since surgery. All patients will be interviewed via telephone. At least two attempts will be made to contact each patient.

Quality of Life After Esophagectomy for Cancer

Role of Pyloric Drainage in Reflux Symptoms After Esophagectomy for Cancer

Comparison of reflux symptoms in patients who underwent open esophagectomies with pyloric drainage and those who received minimally invasive esophagectomies without pyloric drainage. The survey consisted of ten questions regarding symptoms associated with reflux using Gastrointestinal Symptoms Rating Scale (GSRS). Responses to degree of reflux distress rated on a six-point scale for questions with "0" indicating no heartburn symptoms and "5" indicating most symptoms experienced.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Quality of Life After Esophagectomy for Cancer	NCT00798746	Esophageal Canc...	Telephone Quest...	18 Years -	M.D. Anderson Cancer Center
Quality of Life After Esophagectomy for Cancer	NCT00798746	Esophageal Canc...	Telephone Quest...	18 Years -	M.D. Anderson Cancer Center
Quality of Life After Esophagectomy for Cancer	NCT00798746	Esophageal Canc...	Telephone Quest...	18 Years -	M.D. Anderson Cancer Center

Spots Global Cancer Trial Database for pyloric drainage