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Hematologic Diseases

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Dynamics of Bone marrow fat fraction by mDixon-quant (%)

Nataliia Kriventsova

Galina f Tereshchenko

Lena Smirnova

The study is aimed at assessing changes in the bone marrow of patients from 6 to 18 years old with a diagnosis of acute lymphoblastic leukemia during chemotherapy. Patients of the same age without hematological diseases will be recruited as a control group.

The ratio of fat to water in the bone marrow depends on the cellularity of the bone marrow. In addition to the water/fat ratio in bone marrow there are also other parameters for quantitative MRI assessment. These include the apparent diffusion coefficient (ACD), the T1 relaxation time, mapping of the macromolecular proton fraction. The undoubted advantage of MRI is its non-invasiveness and the ability to assess any localization of the bone marrow.

MRI may become a new non-invasive method for assessing the ratio of fat to cells in the bone marrow in children with hematological malignancies, which can help in making a diagnosis and monitoring the response to therapy.

Quantitative MRI of Bone Marrow in Patients With Acute Lymphoblastic Leukemia

Clinical Pilot Study of Quantitative MRI Assessment of Bone Marrow in Patients With Acute Lymphoblastic Leukemia and Patients Without Hematopoietic Disorders, From 6 to 18 Years Old

T1 mapping is a magnetic resonance imaging technique used to calculate the T1 time

Apparent diffusion coefficient (ADC) is a measure of the magnitude of diffusion (of water molecules) within tissue, and is commonly clinically calculated using MRI with diffusion-weighted imaging (DWI).

Fat fraction (FF)-this is the ratio of unconfounded fat signal to the sum of the unconfounded fat and water signals

The macromolecular proton fraction (MPF) is a quantitative MRI parameter determining the magnetization transfer (MT) effect in tissues, and is defined as the relative amount of immobile macromolecular protons involved in magnetization exchange with mobile water protons.

Federal Research Institute of Pediatric Hematology, Oncology and Immunology

Nervous System Diseases

Substance Related Disorders

Neurotoxicity Syndromes

The quantitative assessment of MRI parameters, The macromolecular proton fraction (MPF) (%) in brain tissue. Before the start of therapy - the starting point. Point 2. 36 ± 3 days after the start of the therapy. Point 3. After completing three courses of consolidation chemotherapy. Point 4. After confirmation of remission status, optionally provided.

Nataliia f Kriventsova

Dmitry Balashov, MD, PhD

Michael Maschan, Professor

The study is aimed at assessing changes in the brain of patients from 6 to 18 years old with a diagnosis of acute lymphoblastic leukemia during chemotherapy.

Children with acute lymphoblastic leukemia receive long-term combined chemotherapy treatment, one of the main part of this treatment is methotrexate. Methotrexate can cause acute, subacute, and long-term neurotoxicity. Clinical symptoms of neurotoxicity, such as seizures, aphasia, are often associated with leukoencephalopathy. However, leukoencephalopathy may develop asymptomatically in children receiving methotrexate.

The effect of chemotherapy on the neurological status of patients is widely covered in the literature. There are very few studies devoted to the quantitative assessment of MRI parameters, especially in children. MRI is a non-invasive method that does not harm the patient and can be used to assess absolutely all structures of the brain.

Evaluation of Brain Changes in ALL Patients on Therapy

Clinical Study of the Therapy Neurotoxicity Using Quantitative Assessment of the Brain Structures and Functions by MRI, EEG and Evoked Potentials in Patients With Acute Lymphoblastic Leukemia Over 6 Years Old

macromolecular proton fraction (MPF) in brain tissue.

T1 mapping (ms) is a magnetic resonance imaging technique used to calculate at 4 time points

value of apparent diffusion coefficient in mm2/s calculated at 4 time points

water myelin fraction calculated at 4 time points

cerebral blood flow (CBF) (ml/100g/min) in brain tissue. calculated at 4 time points

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Quantitative MRI of Bone Marrow in Patients With Acute Lymphoblastic Leukemia	NCT04767165	Acute Leukemia	MRI	6 Years - 18 Years	Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Evaluation of Brain Changes in ALL Patients on Therapy	NCT04767152	Acute Leukemia	MRI	6 Years - 18 Years	Federal Research Institute of Pediatric Hematology, Oncology and Immunology

Spots Global Cancer Trial Database for quantitative mri