Neoplasms

Digestive System Diseases

Gland and Hormone Related Diseases

All Conditions

Rare Diseases

Pancreatic Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Endocrine Gland Neoplasms

Gastrointestinal Diseases

Pancreatic Diseases

Endocrine System Diseases

Pancreatic Cancer

Patients with pancreatic cancer treated by traditional open surgery

Patients with pancreatic cancer treated by laparoscopic surgery

Eligible patients diagnosed as left-side pancreatic cancer in MI-RAMPS group will be treated by minimal invasive RAMPS surgery

Minimal Invasive RAMPS

Eligible patients diagnosed as left-side pancreatic cancer in Open-RAMPS group will be treated by open invasive RAMPS surgery

Open RAMPS

HANYU ZHANG, M.D.

Yatong Li, M.D.

Menghua Dai, M.D.

Pancreatic cancer is regarded as "the king of cancer". It is extremely malignant, with a low sensibility to chemotherapy and radiotherapy, and a poor prognosis. Surgical treatment is very important for pancreatic cancer. Radical antegrade modular pancreatosplenectomy (RAMPS) is a standard method for treating pancreatic cancer at the body and tail of pancreas. In the same surgical approach, the investigators are going to compare and discuss the advantages of laparoscopic and open RAMPS in the RCT study.

Open RAMPS is widely used now to treat pancreatic cancer at the body and tail of pancreas. Meanwhile, laparoscopic surgery is proved to have many advantages in other operations. According to primary retrospective study of open and laparoscopic RAMPS, there was no statistically significant difference in the long-term follow-up situations between these two groups, indicating the safety of both this two surgical approaches. The investigators would like to promote a prospective RCT study, to give more evidences of the superiority of laparoscopic RAMPS.

The development of study model was divided into 2 parrallel groups( Minimal Invasive RAMPS vs. Open RAMPS) based on the certain surgical procedure underwent

The Therapeutic Evaluation(Both Short-term and Long-term Outcome) of Minimal Invasive Radical Antegrade Modular Pancreatosplenectomy for Left-sided Pancreatic Cancer Patients

Minimal Invasive Versus Open Radical Antegrade Modular Pancreatosplenectomy for Left-sided Pancreatic Cancer: a Randomized Controlled Trial

IPD is not avaiable, but statistical data is avaiable

The days between the postoperative day-1 to the date when patient was eligible to be discharged.

DFS means the survival duration after surgery.

VAS score to measure the degree of postoperative pain

The ratio between patients with complication(s) and total patients in each groups.

DFS means the survival duration after surgery without any evidence of recurrence and metastasis.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
The Therapeutic Evaluation(Both Short-term and Long-term Outcome) of Minimal Invasive Radical Antegrade Modular Pancreatosplenectomy for Left-sided Pancreatic Cancer Patients	NCT03770559	Pancreatic Canc... Surgery	Minimal Invasiv... Open RAMPS	18 Years -	Peking Union Medical College Hospital
The Therapeutic Evaluation(Both Short-term and Long-term Outcome) of Minimal Invasive Radical Antegrade Modular Pancreatosplenectomy for Left-sided Pancreatic Cancer Patients	NCT03770559	Pancreatic Canc... Surgery	Minimal Invasiv... Open RAMPS	18 Years -	Peking Union Medical College Hospital

Spots Global Cancer Trial Database for radical antegrade modular pancreatosplenectomy(ramps)