Neoplasms

All Conditions

Symptoms and General Pathology

Carcinoma

Recurrence

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Disease Attributes

Antineoplastic Agents

All Drugs and Chemicals

Paclitaxel

Carboplatin

Albumin-Bound Paclitaxel

Tubulin Modulators

Antimitotic Agents

Paclitaxel 175 mg/ m2 administered in 250 ml normal saline over 3 hours and carboplatin AUC 4-5 administered in 250 ml 5%D over 2 hours. Therapy repeated every three weekly

Paclitaxel 60 mg/ m2 administered in 250 ml normal saline over 1 hour and carboplatin AUC 2 administered in 250 ml 5%D over 1 hour. Therapy repeated every weekly

Paclitaxel 60 mg/ m2 administered in 250 ml normal saline over 1 hour, and carboplatin AUC 2 administered in 250 ml 5%D over 1 hour. Therapy repeated every weekly

Paclitaxel and carboplatin

lalit kumar, MD,DM

Experience with substituting carboplatin for cisplatin is limited in advanced and recurrent cervix cancer and there has been no counterpart to GOG 158, which documented therapeutic equivalency of cisplatin/paclitaxel and carboplatin/paclitaxel for treatment of ovarian cancer, performed in a cervix cancer population.

This trial will be a prospective, randomized phase II pilot study. Consecutive patients of metastatic, recurrent or refractory carcinoma cervix enrolled in gynecology clinic at IRCH, AIIMS will be taken into study after taking informed consent. Patients will be randomized into two arms. Each arm shall contain 20 patients. The patients shall receive paclitaxel and carboplatin q3wk in first arm and paclitaxel and carboplatin q1 wk in second arm.

Effectiveness of Chemotherapy in Metastatic or Recurrent Carcinoma Cervix

An Open Label Randomized Phase 2, Pilot Study to Investigate the Effectiveness of Palliative Chemotherapy in Stage IVB, Recurrent or Persistent Carcinoma Cervix

All India Institute of Medical Sciences, New Delhi

senior resident

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Effectiveness of Chemotherapy in Metastatic or Recurrent Carcinoma Cervix	NCT02492503	Metastatic Carc... Recurrent Carci... Cervix Carcinom...	Paclitaxel and ... Paclitaxel and ...	18 Years - 70 Years	All India Institute of Medical Sciences, New Delhi
Effectiveness of Chemotherapy in Metastatic or Recurrent Carcinoma Cervix	NCT02492503	Metastatic Carc... Recurrent Carci... Cervix Carcinom...	Paclitaxel and ... Paclitaxel and ...	18 Years - 70 Years	All India Institute of Medical Sciences, New Delhi

Spots Global Cancer Trial Database for recurrent or metastatic carcinoma cervix chemotherapy