Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Symptoms and General Pathology

Nervous System Diseases

Rare Diseases

Breast Neoplasms

Chronic Pain

Pain

Neurologic Manifestations

Chronic Graft Versus Host Disease

Quantitative sensory testing (QST) of healthy women to create reference values for QST evaluation of women treated for breast cancer

Testing with thermal sensor testing device, von Frey filaments, cotton wisp, turning fork, pressure gauge device

Niels Kroman, MD, DMSc

Henrik Kehlet, MD Ph.D DMSc

The purpose of this study is to identify intraindividual as well as iatrogenic factors disposing for the development of chronic and acute pains after surgery for breast cancer in order to improve treatment and prevent the development of acute and chronic postoperative pains.

Surgery for breast cancer is followed by acute undesirable sequelae (pain, nausea, vomiting, psycho-social adaptation) and late sequelae with discomfort or more severe neuropathic pain problems in the surgical area due to nerve damage or adjuvant-/radiotherapy. The late sequelae occur in 30-50% of patients but the exact mechanisms (preoperative disposing factors, intraoperative nerve damage/inflammatory response), acute postoperative pain and psychosocial factors remain to be determined in large, detailed, well-described studies, including stratification to modern breast cancer treatment (sentinel node strategy/ radiotherapy/ chemotherapy). The present study will describe in detail preoperative psychosocial/genetic pain mechanisms, intraoperative technique, multi-modal anaesthesia and opioid-reduced analgesia with a detailed, early and late postoperative follow-up with neurophysiological assessment in the surgical area and randomised studies on preventive therapy.

Chronic Pain After Operation for Breast Cancer

Examination of Healthy Female Subjects in the Project: Disposing Factors for Chronic Pain After Operation for Breast Cancer

Danish Breast Cancer Cooperative Group

Danish Cancer Society

Rigshospitalet, Denmark

Rune Gärtner MD

Blood and Lymph Conditions

Head and Neck Neoplasms

Lymphedema

Neoplasm Metastasis

Lymphatic Diseases

Selected measurements in healthy persons of skin tissue dielectric constant as reference values for subsequent use to evaluate patients with head and neck lymphedema.

Skin tissue dielectric constant (TDC) measurements will non-invasively be made bilaterally at two neck sites, bilaterally on two forearm sites and one site at the chin sub-mental area.

Measurements are made with subjects fully clothed and seated. Measurements are made in triplicate and averaged at each site. Full measurements take about 5-7 minutest to complete. Data will be analyzed to determine the neck-to-arm ratios and chin-to-arm ratios to establish normal ranges of these parameters for subsequent use as comparisons to evaluate and track changes in patients with head and neck lymphedema.

Skin Biophysical Measures for Assessing Head and Neck Cancer-Related External Lymphedema

Bilateral values and Variability in TDC values

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Chronic Pain After Operation for Breast Cancer	NCT00739544	Pain Threshold	1	18 Years - 70 Years	Rigshospitalet, Denmark
Skin Biophysical Measures for Assessing Head and Neck Cancer-Related External Lymphedema	NCT04457375	Lymphedema, Sec...	TDC	18 Years -	Nova Southeastern University
Chronic Pain After Operation for Breast Cancer	NCT00739544	Pain Threshold	1	18 Years - 70 Years	Rigshospitalet, Denmark

Spots Global Cancer Trial Database for reference values