Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

All Conditions

Behaviors and Mental Disorders

Rare Diseases

Carcinoma, Renal Cell

Kidney Neoplasms

Carcinoma

Urologic Neoplasms

Urogenital Neoplasms

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Kidney Diseases

Urologic Diseases

Male Urogenital Diseases

Adenocarcinoma

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Quality of Life

Renal Cell Carcinoma

Patients with kidney cancer who underwent radical or partial kidney removal surgery

Removal of neoplastic mass either by full kidney excision or by targeted cancer removal

Radical or partial nephrectomy

Francesco Montorsi, MD.

Francesco Fiorio, MSC

Francesco Montorsi, MD

The aim of this observational study is to gather pre and post surgery clinical data belonging to patients who underwent radical or partial nephrectomy and to evaluate the impact of the surgery on the quality of life of the patients, as well as possible relapses within a 10 year period.

A databasa was created with the intention of collecting data related to patients who underwent radical or partial nefrectomy surgery in an electronic case report form.

Each patient will be followed for 10 years approximately starting from the date of surgery for a total of 2 yearly visits for the first 5 years which could then be diluted in 1 visit per year for the remaining 5 years. At each visit control exams forseen by the standard care for post surgery patients will be evalued and tha data will then be transferred into the database. Yearly, a follow up questionnaire will be sent to the patients' home in order to obtain the information relative to possible relapses. The data collected will be handled following the most strict GCPs and privacy norms. The main objectives of the study are the collection and interpretation of the scientific data with the scope of: obtaining health benefits for the patients involved and for future patients with the same type of cancer, improving the scientific knowledge on the pathology and implementing new strategies for diagnosis and therapy and evaluating the epidemiologic changes of renal neoplasia.

Kidney Cancer Observational Protocol

2007 - Rene: Observational Study on the Occurrence of Possible Relapses and on the Quality of Life in Patients Who Underwent Radical Nefrectomy/Tumorectomy Surgery

Collection intended for the purpose of implementing diagnostic and therepautic strategies for the management of the disease in both the patient enrolled in the study and for future cases.

IRCCS San Raffaele

Professor

Symptoms and General Pathology

Ischemia

Partial nephrectomy will be performed without clamping of the renal blood vessels.

Partial nephrectomy will be performed with clamping of the renal blood vessels.

Off-clamp partial nephrectomy

Robert S Figenshau, MD

The purpose of this research study is to compare the effects on kidney function after performing the removal of a kidney tumor with or without clamping the blood vessels during surgery.

Off Clamp Randomization

Evaluation of the Off-Clamp Robot-Assisted Partial Nephrectomy Technique in the Management of Renal Tumors

Renal function following nephrectomy with and without clamping will be assessed using: percent change in eGFR from baseline to 3 months post nephrectomy.

Renal function following nephrectomy with and without clamping will be assessed using: percent change in split renal function from baseline to 3 months post nephrectomy.

Oncologic outcomes will be assessed at the time of nephrectomy based on percent of observations with positive surgical margins.

Perioperative outcomes will be assessed based on estimated blood loss at the time of nephrectomy.

Oncologic outcomes will be assessed based on percent of observations with metastasis on follow-up imaging at 3 years post nephrectomy.

Perioperative outcomes will be assessed based on operative time measured in minutes at the time of nephrectomy.

Perioperative outcomes will be assessed based on warm ischemia time measured in minutes at the time of nephrectomy.

Perioperative outcomes will be assessed based on percent of observations with intra-operative complications at the time of nephrectomy.

Perioperative outcomes will be assessed based number of hospital days post nephrectomy.

Perioperative outcomes will be assessed based on percent of observations with postoperative complications.

Midwest Stone Institute.

Washington University School of Medicine

Partial nephrectomy will be performed without clamping of the renal blood vessels.

Off-clamp partial nephrectomy

Off-clamp Partial Nephrectomy

Traditional Partial Nephrectomy

Total

Age, Continuous

Sex: Female, Male

Race (NIH/OMB)

United States

Region of Enrollment

Manager of Clinical Trials

Missing 3 postoperative eGFR from the Traditional Partial Nephrectomy group and 6 from the Off-Clamp Partial Nephrectomy group.

Percent Change From Baseline in eGFR

Missing 1 postoperative renal scan from the Traditional Partial Nephrectomy group and 7 from the Off-Clamp Partial Nephrectomy group.

Percent Change From Baseline in Split Renal Function

Only malignant cases were included in the analysis of positive margins.

Percent of Observations With Positive Surgical Margins.

Estimated Blood Loss

Only malignant cases were included in the analysis of metastasis on follow-up imaging.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Kidney Cancer Observational Protocol	NCT06147349	Renal Cancer	Radical or part...	18 Years -	IRCCS San Raffaele
Off Clamp Randomization	NCT01732120	Renal Cancer Renal Ischemia	Off-clamp parti...	18 Years -	Washington University School of Medicine
Kidney Cancer Observational Protocol	NCT06147349	Renal Cancer	Radical or part...	18 Years -	IRCCS San Raffaele

Spots Global Cancer Trial Database for renal cancer treatment