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Patients diagnosed with cancer and treated with chemotherapy and/or radiotherapy

* Cardiorespiratory exercise test to evaluate the exercise tolerance
* Cardiac imaging for the assessment of the left atrium anatomy and function.

Cardiorespiratory exercise test

Steven Droogmans, Professor

Steven Droogmans, PhD

Luiza Luchian

Bernard Cosyns, Professor

This study regarding oncological patients for rehabilitation after specific cancer therapy involves three aims: (1) to evaluate the predictive value of myocardial work parameters on the improvement of exercise performance after rehabilitation, (2) to determine which echocardiographic parameters are more suitable in predicting cardiac dysfunction, and (3) to evaluate the correlation between echocardiographic parameters and fibrosis detected by cardiac magnetic resonance imaging (CMR).

Myocardial work (MW) provides an estimation of cardiac function by combining global longitudinal strain (GLS) with blood pressure values obtained non-invasively, being less load dependent than standard GLS. The investigator hypothesize that myocardial work could be a useful marker for predicting the exercise performance after chemotherapy and/or radiotherapy in oncological patients undergoing rehabilitation. Moreover, this study may provide additional information in optimal selection for rehabilitation programs.

Exercise Response After Revalidation in Cancer Patients

Role of Myocardial Work in the Prediction of Cardiac Dysfunction and Response After Revalidation in Patients With Cancer Undergoing Chemotherapy and/or Radiotherapy

represents the maximum oxygen consumption during incremental exercise that is measured during Cardiopulmonary Exercise test (CPET), being a measure of aerobic capacity of the subject

this parameter shows the increase in ventilation in response to CO2 production, thus it measures the ventilatory efficiency

represents the ratio between exhaled CO2 and inhale O2 may quantify the grade of the effort

Myocardial work (MW) is a non-invasive, less load-dependent echocardiographic parameter obtained during standard transthoracic echography using the pressure-strain loop data.

This parameter consists of the following measurements: Global constructive work (GCW) Global wasted work (GWW), Global work index (GWI), and Global work efficiency (GWE)

Self-assessment of the generic health status using the EQ-5D-5L questionnaire. This questionnaire assesses health status in terms of five dimensions: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression, on a five-level scale.

In the evaluation part, the respondents evaluate their overall health status using the visual analogue scale (EQ-VAS) from 0 ('the worst health you can imagine') - 100 ('the best health you can imagine')

nonfatal stroke, nonfatal myocardial infarction, and cardiovascular death

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Exercise Response After Revalidation in Cancer Patients	NCT04461392	Oncology Cardiac Toxicit...	Cardiorespirato...	18 Years - 90 Years	Universitair Ziekenhuis Brussel
Exercise Response After Revalidation in Cancer Patients	NCT04461392	Oncology Cardiac Toxicit...	Cardiorespirato...	18 Years - 90 Years	Universitair Ziekenhuis Brussel

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