Neoplasms

All Conditions

Digestive System Diseases

Gland and Hormone Related Diseases

Rare Diseases

Adenocarcinoma

Pancreatic Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Endocrine Gland Neoplasms

Gastrointestinal Diseases

Pancreatic Diseases

Endocrine System Diseases

Pancreatic Cancer

Antineoplastic Agents

All Drugs and Chemicals

Gemcitabine

Rubitecan

Topoisomerase I Inhibitors

Enzyme Inhibitors

Patients will be treated with gemcitabine and Orathecin (rubitecan) capsules to evaluate the current estimate of overall survival as a study endpoint prior to launching the blinded randomized phase (versus gemcitabine and placebo) of the study. Toxicity of the drug combination will also be evaluated.

Orathecin + Gemcitabine Versus Placebo + Gemcitabine in Chemonaive Non-Resectable Pancreatic Cancer

Randomized Trial of Orathecin and Gemcitabine Versus Placebo and Gemcitabine in Patients With Non-Resectable Pancreatic Cancer Who Have Not Already Received Chemotherapy

Astex Pharmaceuticals, Inc.

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Renal Insufficiency

Cancer patients with liver or renal dysfunction will be treated with rubitecan capsules to define the maximum tolerated dose and the dose-limiting toxicity in this patient population, and to perform pharmacokinetic studies of rubitecan in this patient population.

Study of Rubitecan in Cancer Patients With Renal or Hepatic Dysfunction

Phase I Study of Rubitecan (RFS 2000) in the Treatment of Cancer Patients With Organ Dysfunction

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Orathecin + Gemcitabine Versus Placebo + Gemcitabine in Chemonaive Non-Resectable Pancreatic Cancer	NCT00113256	Pancreatic Canc...	Rubitecan	18 Years -	Astex Pharmaceuticals, Inc.
Study of Rubitecan in Cancer Patients With Renal or Hepatic Dysfunction	NCT00113113	Tumors	Rubitecan	18 Years -	Astex Pharmaceuticals, Inc.
Study of Rubitecan in Cancer Patients With Renal or Hepatic Dysfunction	NCT00113113	Tumors	Rubitecan	18 Years -	Astex Pharmaceuticals, Inc.

Spots Global Cancer Trial Database for rfs 2000

Every month we try and update this database with for rfs 2000 cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for rfs 2000

Every month we try and update this database with for rfs 2000 cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for rfs 2000 cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.