Musculoskeletal Diseases

All Conditions

Infections

Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Symptoms and General Pathology

Skin and Connective Tissue Diseases

Arthritis

Uterine Cervical Neoplasms

Communicable Diseases

Spondylitis

Rheumatic Diseases

Spondylarthritis

Papillomavirus Infections

Bone Diseases

Bone Diseases, Infectious

Spinal Diseases

Joint Diseases

Female patients (18 to 65 years old) with spondyloarthritis or rheumatoid arthritis will undergo HPV screening and a have a close gynecologic follow-up.

Cervical smear will be obtained using an Ayre spatula and a cervical brush (Cervex-Brush®). HPV test will be performed using the CLART® HPV2 kit (Genomica).This kit enables the detection of 35 genotypes: HPV6, 11, 16, 18, 26, 31, 33, 35, 39, 40, 42, 43,44, 45, 51, 52, 53, 54, 56, 58, 59, 61, 62, 66, 68, 70, 71, 72, 73, 81, 82, 83, 84, 85 et 89.

Cervical smear

Pregnancy test

Sexual activity questionnary

Fabienne COURY-LUCAS, MD

Gery Lamblin, MD

Gery Lamblin

Emmanuelle VIGNOT, MD

Emmanuelle Vignot, MD

Fabienne Coury-lucas, MD

Muriel PIPERNO, MD

Jean-Paul LARBRE, MD

Nathalie HOEN, MD

Rheumatoid arthritis (RA) and spondyloarthritis (SpA) are the two most common chronic inflammatory rheumatism, with a prevalence in the French population of 0.3% and 0.4%, according to the criteria European League Against Rheumatism / American College of Rheumatology (EULAR / ACR) 2010 and Assessemnt of SpondyloArthritis International Society (ASAS) 2009 respectively. In patients whose pathology is resistant to first-line treatment, such as methotrexate for rheumatoid arthritis and peripheral spondyloarthritis, or non-steroidal anti-inflammatory drugs for axial spondyloarthritis, the treatment is based on biotherapies, such as anti-inflammatory drugs. -TNF, to obtain effective control of the disease and prevent joint damage.

Human papillomavirus (HPV) infection, the leading risk factor for cervical carcinoma, is the most common sexually transmitted infection (STI) with a particularly high prevalence among young women.

In addition, anti-TNF, used in the treatment of RA and SpA, and anti-IL6 receptor, used in that of RA, could have opposite effects on HPV-dependent oncogenesis.

Thus, patients with RA or SpA may have a higher risk than the general population of progression to cervical cytological abnormalities. Evaluation of the chronic carriage of HPV would then be a useful tool in the management of these patients.

Papillomavirus Load in Rheumatic Inflammatory Diseases

Papillomavirus chronic load is defined as a positive HPV test at the end of the study combined with at least 3 positive HPV tests during the 24 months follow-up.

Number of patients with a positive HPV test at enrollment

Number of patients with a negative HPV test at enrollment and having at least one positive HPV test during the 24 months follow-up

Number of patients with a positive HPV test at enrollment and having a negative HPV test at the end of the study.

Number of patients with low-grade and high-grade cytological abnormalities during follow-up among those who had normal cytology at enrollment.

Number of patients ,with normal cytology at enrollment, whose cervical smear indicates a regression in cytological abnormalities or a persistence of cytological abnormalities or a development of abnormalities into cervical cancer or dysplasia, during the 24 months follow-up.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Papillomavirus Load in Rheumatic Inflammatory Diseases	NCT03713736	Spondyloarthrit... Rhumatoid Arthi...	Cervical smear Pregnancy test Sexual activity...	18 Years - 65 Years	Hospices Civils de Lyon
Papillomavirus Load in Rheumatic Inflammatory Diseases	NCT03713736	Spondyloarthrit... Rhumatoid Arthi...	Cervical smear Pregnancy test Sexual activity...	18 Years - 65 Years	Hospices Civils de Lyon

Spots Global Cancer Trial Database for rhumatoid arthritis