Neoplasms

Gland and Hormone Related Diseases

All Conditions

Thyroid Neoplasms

Thyroid Diseases

Thyroid Nodule

Endocrine System Diseases

Endocrine Gland Neoplasms

Head and Neck Neoplasms

Potentially cancerous thyroid nodules were assessed by elastrography, then a fine needle biopsy specimen or the surgically-excised nodule was assessed pathologically to determine cancer status.

Siemens Acuson S3000 ultrasound system

Aya Kamaya

This clinical trial studies how well ultrasound elastography works in assessing the cancer status of potentially malignant thyroid nodules.

PRIMARY OBJECTIVES:

Determine the utility of ultrasound elastography in evaluation of thyroid nodules being evaluated for the presence of cancer.

Elastography measures the passages of ultrasound shear waves through tissue to gauge the stiffness and compressibility of the tissue, collectively "tissue stiffness," and may be a better way to image thyroid nodules. Tissue stiffness is a physiological parameter that is being evaluated for differences between non-cancerous (benign) and cancerous thyroid nodules.

Participants will undergo elastography over the 10 minutes prior to either fine needle aspiration of a biopsy specimen or surgical resection of the thyroid nodule. Tissue specimens from the biopsy specimen or surgical resection will be assessed pathologically to determine actual cancer status.

Ultrasound Elastography in Imaging Patients With Thyroid Nodules

Elastography in Thyroid Nodule Evaluation

Potentially cancerous thyroid nodules will be assessed elastographically, and cancer status will be determined from a fine needle aspiration biopsy results or the surgically excised nodule. The outcome will be reported as median tissue stiffness with standard deviation for nodules that were determined non-cancerous (benign), cancerous, or indeterminate.

Stanford University

Professor of Radiology

Potentially cancerous thyroid nodules were assessed by elastrography, then a fine needle biopsy specimen or the surgically-excised nodule was assessed pathologically to determine cancer status.

Siemens Acuson S3000 ultrasound system: Shear Wave Elastography

Tissue Stiffness by Elastography

Age, Categorical

Age, Continuous

Sex: Female, Male

Ethnicity (NIH/OMB)

Race (NIH/OMB)

United States

Region of Enrollment

Aya Kamaya, Professor of Radiology

Pathologically Noncancerous Thyroid Nodules

Pathologically Cancerous Thyroid Nodules

Pathologically Indeterminate Thyroid Nodules

An individual participant could contribute multiple nodules.

Stiffness of Thyroid Nodules as Measured by Elastography

Overall Study

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Ultrasound Elastography in Imaging Patients With Thyroid Nodules	NCT03174925	Malignant Thyro... Thyroid Gland N...	Siemens Acuson ...	18 Years -	Stanford University
Ultrasound Elastography in Imaging Patients With Thyroid Nodules	NCT03174925	Malignant Thyro... Thyroid Gland N...	Siemens Acuson ...	18 Years -	Stanford University

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