Neoplasms

All Conditions

Respiratory Tract (Lung and Bronchial) Diseases

Carcinoma

Carcinoma, Non-Small-Cell Lung

Lung Neoplasms

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Female, non-smoker, non-small cell lung cancer

Female, non-smokers, no lung cancer or other types of cancers' healthy population

Chen Kexin, M.D., Ph.D

To study the association of Genetic Polymorphisms with Lung Cancer Risk in Tianjin Population.

Eligibility criteria:

* nonsmoker
* female
* age between 35 and 80
* no other types of tumors history
* frequency-matched cases and controls on gender and age

Outcome measures:

* OR(odds ratio)
* RR(risk ratio)
* CI(confidence interval)
* SAS software

Peripheral blood sample (10 ml) was collected from each study subject. Buffy coats were isolated and frozen for DNA extraction.

GWAS Research of Lung Cancer in Tianjin

GWAS Research of Lung Cancer by Department of Epidemiology and Biostatistics in Tianjin Medical University Cancer Institute and Hospital

A GWAS reported a novel association between the TP63 locus and risk of lung adenocarcinoma; however, this association did not achieve genome-wide significance among never-smoking males or females. We genotyped the TP63 SNPs reported by the previous GWAS (rs10937405 and rs4488809) in 500 never-smoking female lung cancer cases and 500 never-smoking female controls from China. Genetic variation in rs10937405 was associated with lung adenocarcinoma. Our findings provide strong evidence that genetic variation in TP63 is associated with risk of lung adenocarcinoma among non-smoking females.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
GWAS Research of Lung Cancer in Tianjin	NCT01255059	Non-small Cell ... Primary Carcino...		35 Years - 80 Years	Tianjin Medical University Cancer Institute and Hospital
GWAS Research of Lung Cancer in Tianjin	NCT01255059	Non-small Cell ... Primary Carcino...		35 Years - 80 Years	Tianjin Medical University Cancer Institute and Hospital

Spots Global Cancer Trial Database for single nucleotide polymorphism(snp)