Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Infections

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Gland and Hormone Related Diseases

Symptoms and General Pathology

Rare Diseases

Breast Neoplasms

Ovarian Neoplasms

Carcinoma, Ovarian Epithelial

Communicable Diseases

Endometrial Neoplasms

Uterine Cervical Neoplasms

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Genital Neoplasms, Female

Urogenital Neoplasms

Uterine Neoplasms

Uterine Diseases

Uterine Cervical Diseases

Ovarian Cancer

Ovarian Epithelial Cancer

Central Nervous System Depressants

All Drugs and Chemicals

Analgesics

Anesthetics

Analgesics, Opioid

Narcotics

Patients who had Major Surgery for gynecologic cancers (cervix, endometrium, ovarian and breast cancer) under balanced anesthesia including opioids between February 2019 and 2020 in Hospital La Paz.

Patients who had Major Surgery for gynecologic cancers (cervix, endometrium, ovarian and breast cancer) under Opioid Free anesthesia between February 2019 and 2020 in Hospital La Paz.

Use of balanced anesthesia including opioids during anesthesia for gynecologic cancer surgery

Opioid

Nicolas Brogly, PhD

Opioid Free Anesthesia (OFA) is a multimodal anesthesia and emerging technique that spares the use of opioids and involve other adjuvant anesthetics, which have demonstrated in vitro influence on immunologic and inflammatory response, as well as in metastatic progression. For these reasons we believe that OFA may positively influence in oncologic patients postoperative recovery and in its disease progression.

After Local Ethics Committee approval, consecutive consenting patients scheduled for major gynecologic oncologic surgery were included between February 2019 and January 2020 in this observational retrospective study. We Compared OFA to standard technique used in our institution and assessed its effect on Postoperative Systemic Inflammatory Response (SIRS), hospital stay, postoperative complications in the following 2 months, cancer progression and mortality 6 months and 12 months after surgery. OFA protocol consisted of a Total IntraVenous Anaesthesia of Propofol, a Dexmedetomidine infusion of 0,8-1,0 mcg/kg/h, together with 0,2-0,3 mg/kg ketamine and lidocaine 1,5 mg/kg in the first hour of surgery. The standard anaesthetic protocol included opioids (Fentanyl 2mcg/kg at induction, and remifentanyl infusion 0,1-0,2 mcg/kg/min) and volatile agents (sevoflurane or desflurane). Patients in both groups received a regional block when possible, dexamethasone 8 mg at induction and paracetamol 1g plus dexketoprofen 50mg at the end of surgery. Continuous variables were compared using unpaired t-test (or Mann-Whitney U test) and categorical variables by Chi-square test. Statistical significance was set at p \< 0.05

patients who Major Surgery for gynecologic cancers (cervix, endometrial, ovarian, vaginal, vulvar and breast cancer)

Opioid Free Anaesthesia in Oncologic Gynaecological Surgery: Is There Any Benefit?

Opioid Free Anaesthesia in Oncologic Gynaecological Surgery: Is There Any Benefit? Retrospective Observational Study

To compare postoperative SIRS (Systemic Inflammatory Response) with C-Reactive Protein plasmatic level

To compare postoperative SIRS (Systemic Inflammatory Response) with Leucocytes Ratio

To compare postoperative SIRS (Systemic Inflammatory Response) with Platelet Level

Complications due to surgery which required hospitalization

To compare cancer recurrence (local and/or metastatic) 12 months after surgical treatment between groups.

To compare cancer survival 12 months after surgical treatment between groups

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Opioid Free Anaesthesia in Oncologic Gynaecological Surgery: Is There Any Benefit?	NCT05448586	Cervix Cancer Endometrial Can... Ovarian Cancer Breast Cancer	Opioid	20 Years - 91 Years	Instituto de Investigación Hospital Universitario La Paz
Opioid Free Anaesthesia in Oncologic Gynaecological Surgery: Is There Any Benefit?	NCT05448586	Cervix Cancer Endometrial Can... Ovarian Cancer Breast Cancer	Opioid	20 Years - 91 Years	Instituto de Investigación Hospital Universitario La Paz

Spots Global Cancer Trial Database for sirs (systemic inflammatory response)