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Proton Beam Therapy - A total dose of up to 70 CGE given at 2.0 CGE per daily fraction for 35 fractions.

A total dose of up to 70 CGE given at 2.0 CGE per daily fraction for 35 fractions.

Proton Beam Therapy

David Grosshans, MD,PHD

The goal of this clinical research study is to learn if proton beam therapy, with or without photon beam radiation therapy, is effective in the treatment of skull base chondrosarcoma. The safety of this treatment will also be studied.

Patients who have skull base chondrosarcoma require complicated treatment because of its challenging location and nearness to critical structures within the brain.

Pathology will be confirmed prior to discussion of the study.

If you are found to be eligible to take part in this study, you will receive proton beam therapy, no sooner than 2 weeks after the last surgery to remove tumor. You will receive proton beam therapy once a day for about 35 treatments (7 weeks). Treatment will be given for 5 days in a row each week (except for Saturdays, Sundays, and holidays) at the Proton Center in Houston. The whole process should take up to 1 hour each day.

If your doctor feels it is necessary, the proton beam therapy may be combined with standard photon therapy.

After the proton beam, and possibly photon beam, therapy, you will be asked to come in for study follow-up visits every year, until the study is completed. At these visits, you will have magnetic resonance imaging (MRI) scans, blood draws (less than 1 teaspoon) to monitor your pituitary function, and neuropsychological testing. For the neuropsychological testing, you will be interviewed and tested by a neuropsychologist to evaluate your memory, fluency (the ability to talk and form words) complex thinking ability, planning ability, and coordination. These tests could last from 1-2 hours. You will also have eye exams performed by an ophthalmologist from MD Anderson and hearing exams. It is anticipated that it will take about 5 years to complete this study.

This is an investigational study. The proton beam center and its treatment are approved by the FDA for patient use. A total of up to 15 patients will take part in this study. All will be enrolled at MD Anderson.

Proton Beam Therapy for Chondrosarcoma

Phase II Evaluation of Proton Beam Therapy for Skull Base Chondrosarcoma

Local recurrence defined as progression on magnetic resonance imaging (MRI) or CT if MRI is contraindicated.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Proton Beam Therapy for Chondrosarcoma	NCT00496522	Chondrosarcoma	Proton Beam The...	-	M.D. Anderson Cancer Center
Proton Beam Therapy for Chondrosarcoma	NCT00496522	Chondrosarcoma	Proton Beam The...	-	M.D. Anderson Cancer Center
Proton Beam Therapy for Chondrosarcoma	NCT00496522	Chondrosarcoma	Proton Beam The...	-	M.D. Anderson Cancer Center

Spots Global Cancer Trial Database for skull base chondrosarcoma