Heart and Blood Diseases

All Conditions

Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Rare Diseases

Hypertension

Carcinoma, Renal Cell

Kidney Neoplasms

Carcinoma

Adenocarcinoma

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Urologic Neoplasms

Urogenital Neoplasms

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Kidney Diseases

Urologic Diseases

Male Urogenital Diseases

Renal Cell Carcinoma

Antineoplastic Agents

All Drugs and Chemicals

Amino Acids

Sunitinib

Tyrosine Kinase Inhibitors

Angiogenesis Inhibitors

Growth Inhibitors

Protein Kinase Inhibitors

Enzyme Inhibitors

Tyrosine

Metastatic cell carcinoma patients before sunitinib treatment, after 4 week on, after 2 week off and finally again 4 week on medication.

Age-matched subjects without known disease.

Dominik Müller, PhD

Here, it is investigated how sunitinib, a tyrosine kinase-inhibitor targeting vascular endothelial growth factor receptors, might influence sodium homeostasis in the skin and if this is related to a well-described treatment side-effect of sunitinib, hypertension.

Tyrosine kinases-inhibitors targeting vascular endothelial growth factor (VEGF)-receptors (RTKIs) are increasingly used in oncology in several metastatic tumor types. These agents are featured by toxicities including hypertension. According to a new insight, sodium in response to a high dietary sodium intake, is accumulated in a hyperosmolar way in the interstitial compartment. In response to this high sodium concentration cells of the mononuclear phagocytic system (MPS) are activated resulting in an increased production of VEGF-C, activation of VEGF type 3 receptors and formation of a lymphatic capillary network, involved in clearance of interstitial sodium. Blockade of stimulation of VEGF-C receptors or depletion of MPS cells in rodents has been associated with salt-sensitive hypertension.

Sunitinib is an orally-active, multitarget RTKI mainly used for the treatment of patients with metastatic renal cancer and imatinib-resistant gastrointestinal stromal tumors. Sunitinib blocks all three VEGF receptors subtypes, including VEGF-receptor type 3.

The investigators hypothesize that treatment of patients with sunitinib is associated with tissue sodium accumulation and this accumulation contributes to the rise in blood pressure. Tissue sodium is measured by using a newly developed 23Na magnetic resonance-imaging (MRI) technique which allows a non-invasive and contrast agent-free sodium content measurement in the muscle and skin of the lower leg.

The effect of the female hormonal cycle on skin sodium homeostasis is unknown, therefore we include here male subjects only.

Sunitinib Treatment on Tissue Sodium Accumulation (TSS2)

Effect of Sunitinib Treatment on Tissue Sodium Accumulation in Patients With Renal Cancer: a Pilot Study

Changes in sodium content measured by 23Na magnetic resonance-imaging (MRI) technique

Concentration of VEGF-C in patients plasma

German Heart Institute

Charite University, Berlin, Germany

MD, PhD

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Sunitinib Treatment on Tissue Sodium Accumulation (TSS2)	NCT04368546	Renal Cell Canc... Hypertension Sodium Imbalanc...	Sunitinib	18 Years - 70 Years	Charite University, Berlin, Germany
Sunitinib Treatment on Tissue Sodium Accumulation (TSS2)	NCT04368546	Renal Cell Canc... Hypertension Sodium Imbalanc...	Sunitinib	18 Years - 70 Years	Charite University, Berlin, Germany
Sunitinib Treatment on Tissue Sodium Accumulation (TSS2)	NCT04368546	Renal Cell Canc... Hypertension Sodium Imbalanc...	Sunitinib	18 Years - 70 Years	Charite University, Berlin, Germany

Spots Global Cancer Trial Database for sodium

Every month we try and update this database with for sodium cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for sodium

Every month we try and update this database with for sodium cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for sodium cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.