Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Lung Neoplasms

Carcinoma, Non-Small-Cell Lung

Airway Obstruction

Carcinoma

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Carcinoma, Bronchogenic

Bronchial Neoplasms

Central Nervous System Depressants

All Drugs and Chemicals

Anesthetics

Anesthetics, General

Stenting of central lesion and subsequent standard palliative treatment and dyspnoea symptom control

Standard palliative treatment and standard dyspnoea symptom control.

Patients will undergo arterial blood gas sampling from the radial artery. This will be done by experienced doctors who are highly skilled in this procedure.

Arterial puncture

Blood samples for baseline biochemistry, full blood count, and clotting screen will be taken. In patients additionally providing optional consent blood will be taken for laboratory based basic science research into lung cancer carcinogenesis and pharmacogenetics. Blood will be taken by qualified and experienced nurses, doctors and phlebotomists.

Venepuncture

Patients randomised into the stenting arm will undergo rigid bronchoscopy under general anaesthetic.

General anaesthetic

Patients randomised into the stenting arm will be admitted overnight for the procedure

Inpatient stays

All patients will be asked to complete a 6 minute walking test at baseline and on day 15. Patients randomised into the stent arm (Arm A) will complete a further 6 minute walking test at 24 hours post-stent

Walking test

All patients will undergo spirometry and flow volume loop assessments at baseline and on day 15.

Spirometry & flow volume loop assessment

For patients randomised to stenting and giving additional voluntary consent, 2 pairs of biopsies of tumour tissue, and 1 pair of biopsies of normal airways tissue will be taken for basic scientific research into lung cancer carcinogenesis, and pharmacogenetics.

Biopsy material

Dr Mary O'Brien

Mary O'Brien

To investigate whether the use of airways stents (metal tubes to open and keep open narrowed airways) together with the standard treatment increases the proportion of patients who can complete a 6min walking distance (6MWD) test at 2 weeks +/- 2days in patients with breathlessness due to lung cancer, when compared to standard treatment alone.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Evaluation of Stents to Open Restricted Airways in Patients With Centrally Placed Non-small Cell Lung Cancer	NCT01003522	Non-small Cell ...	Arterial punctu... Venepuncture General anaesth... Inpatient stays Walking test Spirometry & fl... Biopsy material	18 Years -	Royal Marsden NHS Foundation Trust
Evaluation of Stents to Open Restricted Airways in Patients With Centrally Placed Non-small Cell Lung Cancer	NCT01003522	Non-small Cell ...	Arterial punctu... Venepuncture General anaesth... Inpatient stays Walking test Spirometry & fl... Biopsy material	18 Years -	Royal Marsden NHS Foundation Trust

Spots Global Cancer Trial Database for spirometry & flow volume loop assessment