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Lugol's solution

This group patients were given Lugol's solution staining from cervical esophagus to esophagogastric junction （downward）during chromemdoscopy.

This group patients were given Lugol's solution staining from esophagogastric junction to cervical esophagus（upward）during chromemdoscopy.

staining from cervical esophagus to esophagogastric junction

staining from esophagogastric junction to cervical esophagus

Xiuli Zuo, MD,PhD

The aim of this study is to compare the effectiveness and safety of spraying Lugol's solution from cervical esophagus to esophagogastric junction (downward) and from esophagogastric junction to cervical esophagus （upward）during chromoendoscopy.

Chromoendoscopy using Lugol's solution is effective for the detection of early esophageal squamous neoplasia. However, there is no study to investigate the sequence of Lugol's staining during endoscopic procedure.

The aim of this study is to compare the effectiveness and safety of spraying Lugol's solution from cervical esophagus to esophagogastric junction (downward) and from esophagogastric junction to cervical esophagus （upward）during chromoendoscopy.

Whether it is More Appropriate to Spray Lugol's Solution From Cervical Esophagus to Esophagogastric Junction

Image quality is blindly quantified by a 4-point scale from the endoscopists. A higher score representing higher image quality.

Detection rate of esophageal squamous cell carcinoma of the two groups.

The 4-point scale was used to assess the tolerance of endoscopist to the esophageal spasm caused by Lugol's solution which prevent endoscopy from passing. 1-4 means the resistance as intolerable, tolerable, mild, or non-existing.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Whether it is More Appropriate to Spray Lugol's Solution From Cervical Esophagus to Esophagogastric Junction	NCT04224363	Esophageal Squa...	staining from c... staining from e...	18 Years - 80 Years	Shandong University
Whether it is More Appropriate to Spray Lugol's Solution From Cervical Esophagus to Esophagogastric Junction	NCT04224363	Esophageal Squa...	staining from c... staining from e...	18 Years - 80 Years	Shandong University

Spots Global Cancer Trial Database for staining sequence