Neoplasms

All Conditions

Symptoms and General Pathology

Nervous System Diseases

Digestive System Diseases

Rare Diseases

Carcinoma

Postoperative Complications

Sarcopenia

Neoplasm Metastasis

Carcinoma, Hepatocellular

Liver Neoplasms

Hyperplasia

Cysts

Hemangioma

Focal Nodular Hyperplasia

Muscular Atrophy

Atrophy

Neuromuscular Manifestations

Neurologic Manifestations

Pathological Conditions, Anatomical

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Liver Diseases

Nodular Regenerative Hyperplasia

Hematinics

All Drugs and Chemicals

Liver Extracts

Major or minor, open or laparoscopic liver resection

Liver resection

Giuseppe Maria Ettorre, Prof

The investigators will investigate the impact of different biometric parameters (Body mass index, sarcopenia, lean muscle mass, hand-grip strength, gait speed, fat composition) on the postoperative outcomes of patients undergoing liver resections.

Major and minor liver resections will be considered as well as open and minimally invasive techniques.

Benign and malignant indications will be included. Patients characteristics and perioperative variables will be considered for analysis.

Short-term outcomes will be evaluated focusing on 90-days morbidity and mortality and readmission rate.

According to the null hypothesis, no difference in postoperative morbidity between the two groups would be expected. To calculate sample size, a 42% morbidity rate would be expected in sarcopenic patients while a 22% rate would be expected in the non-sarcopenic group. Considering a two-sided α=0.05 and β=0.1, the minimal sample size required to achieve statistical significance was 224 subjects. Considering a 10% drop-out rate of patients undergoing explorative laparoscopy or laparotomy without parenchymal resection a total of 249 patients will be required for completion of the study

Impact of Sarcopenia on Postoperative Outcomes of Patients Undergoing Liver Resection

The Impact of Sarcopenia, Body Composition and Other Biometric Parameters on the Postoperative Outcomes of Patients Undergoing Liver Resection for Different Indications

Patients experiencing medical or surgical complications after surgery

patients readmitted to hospital after discharge

San Camillo Hospital, Rome

Resident in Surgery, Principal Investigator

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Carcinoma, Renal Cell

Kidney Neoplasms

Urologic Neoplasms

Urogenital Neoplasms

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Kidney Diseases

Urologic Diseases

Male Urogenital Diseases

Adenocarcinoma

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Renal Cell Carcinoma

Data source and study cohort:

We conducted a retrospective cohort study using the Premier Healthcare Database (PHD, Premier Inc., Charlotte, NC), an extensive, US hospital-based, all-payer database representing approximately 20% of annual United States inpatient discharges at community and academic centers. The International Classification of Diseases, ninth revision (ICD-9), and tenth revision (ICD-10) procedure codes were used to identify patients who had undergone elective kidney cancer surgery between the 15 years of study from 2003 to 2017. The cohort was then restricted based on appropriate ICD-9 and ICD-10 diagnosis codes to ensure that surgery was performed for a kidney mass. The study cohort was also limited to adult patients (age \>= 18 years), "elective" cases based on administrative codes, as well as surgery on hospital day zero or one to minimize outlier patients who could skew the surgical outcomes.

Outcomes:

The primary outcome of this study was the 90-day complication rate. Complication rates were based on the Clavien-Dindo classification of surgical complications and divided into four categories: no complications, minor complications (Clavien grades 1, 2), and non-fatal major complications (Clavien grades 3, 4), and mortality (Clavien grade 5). Clinical systems also categorized complications (bleeding, cardiac, endocrine, gastrointestinal, infection, neurology, pulmonary, renal, soft tissue, urologic, venous thromboembolism) using Health Care Cost and Utilization Project Clinical Classification Software Level II or III designations; of note, the category for "surgical" complications was excluded given that all complications captured in this analysis are considered surgical complications. Secondary outcomes included patient disposition, length of hospital stay, and readmission rate.

The Association of Marital Status With Kidney Cancer Surgery Morbidity

Complication rates were based on the Clavien-Dindo classification of surgical complications and divided into four categories: no complications, minor complications (Clavien grades 1, 2), and non-fatal major complications (Clavien grades 3, 4), and mortality (Clavien grade 5).

patient disposition was divided into home and none home such as skilled nursing or rehabilitation facility

readmission was defined as readmitted into the hospital for any reason

Brigham and Women's Hospital

Beijing Tsinghua Chang Gung Hospital

Clinical Attending

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Impact of Sarcopenia on Postoperative Outcomes of Patients Undergoing Liver Resection	NCT03630978	Liver Neoplasms Sarcopenia Postoperative C...	Liver resection	18 Years -	San Camillo Hospital, Rome
The Association of Marital Status With Kidney Cancer Surgery Morbidity	NCT05526599	Marriage Kidney Neoplasm... Surgery-Complic... Cohort Studies		18 Years -	Beijing Tsinghua Chang Gung Hospital

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