Wounds and Injuries

All Conditions

Symptoms and General Pathology

Musculoskeletal Diseases

Neoplasms

Skin and Connective Tissue Diseases

Nervous System Diseases

Fractures, Bone

Edema

Contracture

Radius Fractures

Hand Injuries

Dupuytren Contracture

Wrist Fractures

Forearm Injuries

Arm Injuries

Wrist Injuries

Joint Diseases

Muscular Diseases

Fibroma

Neoplasms, Fibrous Tissue

Neoplasms, Connective Tissue

Neoplasms, Connective and Soft Tissue

Neoplasms by Histologic Type

Connective Tissue Diseases

Coagulants

All Drugs and Chemicals

Central Nervous System Depressants

Anti-Infective Agents

Tranexamic Acid

Anesthetics

Anti-Bacterial Agents

Antibiotics, Antitubercular

Hemostatics

Antifibrinolytic Agents

Patients in the TXA arm will receive 1 gram dose of intravenous (IV) tranexamic acid mixed with 50cc 0.9% sodium chloride before their surgery and 1 gram dose of intravenous (IV) tranexamic acid mixed with 50cc 0.9% sodium chloride 3-6 hours after the first dose on the day of their surgery

Patients in the (SOC) arm will receive 50cc of IV Placebo (standard intravenous normal saline fluid - 0.9% sodium chloride) before their surgery and 50cc of IV Placebo (standard intravenous normal saline fluid - 0.9% sodium chloride) 3-6 hours after the first dose on the day of their surgery

Patients will receive 1 gram dose of intravenous (IV) tranexamic acid mixed with 50cc 0.9% sodium chloride before your surgery and 1 gram dose of intravenous (IV) tranexamic acid mixed with 50cc 0.9% sodium chloride 3-6 hours after your first dose on the day of your surgery

Tranexamic acid

This will include regional anaesthesia, tourniquet inflation to 250mmHg and perioperative antibiotics. At the conclusion of the procedure hemostasis will be achieved followed by standard closure technique. There will be three separate surgical groups that will undergo the outlined study protocol: 1) Distal radius fractures will be treated with open reduction from a volar approach only technique 2) Mild dupuytren's: a. Low: i. MCP joints \<50 contracture ii. PIP joints \<40 contracture b. 1-2 fingers involved 3) Severe dupuytren's a. High: i. MCP joints \>50 degree contracture ii. PIP Joints \>40 degrees contracture b. \>2 fingers involved

Surgery

Hand edema following hand surgery is a common yet devastating side effect that can lead to early stiffness, prolonged rehabilitation and diminished function. These factors can reduce a patient's quality of life; mounting to an overall delay in recovery, return to work and daily activities. Conventional edema therapy includes cryotherapy, external compression, active and passive exercises and various types of massage. However, there is little evidence to suggest these modalities are effective. Tranexamic acid (TXA) is an antifibrinolytic that has been used in surgical disciplines for decades to aid in reducing intraoperative blood loss and consequent transfusions. Recently, the use of TXA for curbing post-operative edema and ecchymosis has shown promising results, however, its use in hand surgery has not been studied.

A Prospective, Randomized Controlled, Double-Blinded Pilot Study

The Role of Tranexamic Acid in Reducing Post Operative Hand Edema After Hand and Wrist Surgery

The Role of Tranexamic Acid in Reducing Post Operative Hand Edema After Hand and Wrist Surgery (THAW): A Prospective, Randomized Controlled, Double-Blinded Pilot Study

Assess number of patients who receive hand volume measurements at all designated time intervals. The outcome goal will be 90%

Asses proportion of patients who correctly receive the intervention as per the protocol. The outcome goal will be 90%

Proportion of participants to complete the study protocol and associated follow up. The outcome goal will be an 80% retention rate

Number of patients recruited to the study per month. The outcome goal will be 5 patients per month

Hand volume will be assessed using two validated methods; water displacement and figure of eight measurement.

Patient Reported Wrist and Hand Evaluation (PRWHE). The PRWHE allows patients to rate their levels of hand and wrist pain and disability. It is rated on a 0-100 scale. A higher score in the scale denotes a worse outcome

Ruby Grewal

Co-director of the clinical research lab within the Roth | McFarlane Hand and Upper Limb Center (HULC)

Behaviors and Mental Disorders

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Infections

Heart and Blood Diseases

Respiratory Tract (Lung and Bronchial) Diseases

Blood and Lymph Conditions

Eye Diseases

Gland and Hormone Related Diseases

Diseases and Abnormalities at or Before Birth

Nutritional and Metabolic Diseases

Rare Diseases

Inflammation

Anxiety Disorders

Kidney Diseases

Schizophrenia

Mental Disorders

Hemorrhage

Communicable Diseases

Migraine Disorders

Heart Failure

Autistic Disorder

Hyperkinesis

Hypertension

Influenza, Human

Epilepsy

Herpes Simplex

Headache

Endocarditis

Bipolar Disorder

Muscle Cramp

Spasm

Arrhythmias, Cardiac

Bradycardia

Pain

Pneumonia

Pulmonary Arterial Hypertension

Urinary Tract Infections

Heart Arrest

Seizures

Respiratory Tract Infections

Psychotic Disorders

Neutropenia

Sepsis

Central Nervous System Infections

Virus Diseases

Intraabdominal Infections

Meningitis

Toxemia

Retinitis

Hyperaldosteronism

Staphylococcal Infections

Schizophrenia, Treatment-Resistant

Healthcare-Associated Pneumonia

Adenoviridae Infections

Hemangioma

Hemangioma, Capillary

Port-Wine Stain

Menorrhagia

Hypokalemia

Potassium Deficiency

Cytomegalovirus Retinitis

Meningitis, Bacterial

Renal Insufficiency, Chronic

Renal Insufficiency

Hemophilia A

Disease Attributes

Vascular Diseases

Heart Diseases

Schizophrenia Spectrum and Other Psychotic Disorders

Urologic Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Male Urogenital Diseases

Lung Diseases

Respiratory Tract Diseases

Chronic Disease

Brain Diseases

Central Nervous System Diseases

Neurologic Manifestations

Bipolar and Related Disorders

Mood Disorders

Hemostatic Disorders

Blood Coagulation Disorders

Blood Coagulation Disorders, Inherited

Hematologic Diseases

Coagulation Protein Disorders

Hemorrhagic Disorders

Genetic Diseases, Inborn

Hypertension, Pulmonary

Herpesviridae Infections

DNA Virus Infections

Skin Diseases

Skin Diseases, Viral

Skin Diseases, Infectious

Agranulocytosis

Leukopenia

Cytopenia

Leukocyte Disorders

Neuroinflammatory Diseases

Retinal Diseases

Autism Spectrum Disorder

Child Development Disorders, Pervasive

Developmental Disabilities

Neurodevelopmental Disorders

Neuromuscular Manifestations

Bacterial Infections

Gram-Positive Bacterial Infections

Analgesics

Antihypertensive Agents

Anti-Dyskinesia Agents

Antiemetics

Psychotropic Drugs

Gastrointestinal Agents

Antineoplastic Agents

Anti-Inflammatory Agents

Natriuretic Agents

Anticoagulants

Neuroprotective Agents

Channel Blockers

Vasodilator Agents

Reproductive Control Agents

Anticonvulsants

Adjuvants, Anesthesia

Bone Density Conservation Agents

Cardiotonic Agents

Anti-Allergic Agents

Dermatologic Agents

Fosfomycin

Vancomycin

Oxycodone

Rocuronium

Bosentan

Haloperidol

Haloperidol decanoate

Ciprofloxacin

Tazobactam

Piperacillin

Amikacin

Piperacillin, Tazobactam Drug Combination

Prednisolone

Alfentanil

Clozapine

Spironolactone

Cefepime

Tobramycin

Warfarin

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
The Role of Tranexamic Acid in Reducing Post Operative Hand Edema After Hand and Wrist Surgery	NCT04907812	Hand Injuries a... Distal Radius F... Dupuytren Contr...	Tranexamic acid Surgery	18 Years -	Lawson Health Research Institute
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care	NCT01431326	Adenovirus Anesthesia Anxiety Anxiolysis Autism Autistic Disord... Bacterial Menin... Bacterial Septi... Benzodiazepine Bipolar Disorde... Bone and Joint ... Central Nervous... Convulsions Cytomegalovirus... Early-onset Sch... Epilepsy General Anesthe... Gynecologic Inf... Herpes Simplex ... Infantile Heman... Infection Inflammation Inflammatory Co... Intra-abdominal... Lower Respirato... Migraines Pain Pneumonia Schizophrenia Sedation Seizures Skeletal Muscle... Skin and Skin-s... Treatment-resis... Urinary Tract I... Withdrawal Sepsis Gram-negative I... Bradycardia Cardiac Arrest Cardiac Arrhyth... Staphylococcal ... Nosocomial Pneu... Neuromuscular B... Methicillin Res... Endocarditis Neutropenia Headache Fibrinolytic Bl... Pulmonary Arter... CMV Retinitis Hypertension Chronic Kidney ... Hyperaldosteron... Hypokalemia Heart Failure Hemophilia Heavy Menstrual... Insomnia	The POPS study ...	- 21 Years	Duke University
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care	NCT01431326	Adenovirus Anesthesia Anxiety Anxiolysis Autism Autistic Disord... Bacterial Menin... Bacterial Septi... Benzodiazepine Bipolar Disorde... Bone and Joint ... Central Nervous... Convulsions Cytomegalovirus... Early-onset Sch... Epilepsy General Anesthe... Gynecologic Inf... Herpes Simplex ... Infantile Heman... Infection Inflammation Inflammatory Co... Intra-abdominal... Lower Respirato... Migraines Pain Pneumonia Schizophrenia Sedation Seizures Skeletal Muscle... Skin and Skin-s... Treatment-resis... Urinary Tract I... Withdrawal Sepsis Gram-negative I... Bradycardia Cardiac Arrest Cardiac Arrhyth... Staphylococcal ... Nosocomial Pneu... Neuromuscular B... Methicillin Res... Endocarditis Neutropenia Headache Fibrinolytic Bl... Pulmonary Arter... CMV Retinitis Hypertension Chronic Kidney ... Hyperaldosteron... Hypokalemia Heart Failure Hemophilia Heavy Menstrual... Insomnia	The POPS study ...	- 21 Years	Duke University

Spots Global Cancer Trial Database for swelling

Every month we try and update this database with for swelling cancer trials from around the world to help patients and their families find trials that might be right for them.
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Spots Global Cancer Trial Database for swelling

Every month we try and update this database with for swelling cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for swelling cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.