Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

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Carcinoma, Non-Small-Cell Lung

Lung Neoplasms

Carcinoma

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Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Carcinoma, Bronchogenic

Bronchial Neoplasms

video-assisted thoracoscopic surgery (VATS) major pulmonary resection with systematic node dissection (SND) for clinical stage IIIA non-small cell lung cancer

VATS

Jianxing He, MD, FACS

Daoyuan Wang, MD

Wenlong Shao, MD

The purpose of this study is to examine the feasibility of video-assisted thoracoscopic surgery (VATS) major pulmonary resection with systematic node dissection (SND) for clinical stage IIIA non-small cell lung cancer. Success is defined as VATS major pulmonary resection with SND without conversion. If success rate over 90%, VATS major pulmonary resection with SND is considered as feasible procedures for clinical stage IIIA non-small cell lung cancer.

Video-assisted or minimally invasive surgery has become the standard approach for many abdominal surgical operations such as cholecystectomy and fundoplication. With respect to the thorax, video-assisted thoracoscopic surgery (VATS) is the accepted technique for biopsy of the lung and pleura and surgical treatment of pneumothorax. A VATS lobectomy with systematic node dissection (SND) for non-small cell lung cancer (NSCLC) has been gradually introduced by many thoracic surgeons since it was first performed in 1995 by McKenna and associates. They reported that the survival rate for stage I lung cancer is similar between lobectomies done by VATS and by thoracotomy. Although minimally invasive surgery certainly sounds good, it is problematic if it decreases patient's safety or the oncological treatment's effect. Hence, the feasibility and safety of SND by VATS remain controversial. In many institutions, the indication for VATS major pulmonary resection is limited to clinical stage I or II. For the application of the procedure to clinical stage IIIA, it remains controversial. Recently, Watanabe et al. did a retrospective study aimed at determining the outcome of patients with cN0-pN2 NSCLC who underwent VATS major pulmonary resection with SND versus the outcome after major pulmonary resection with SND by open thoracotomy. It demonstrated that VATS major pulmonary resection with SND was a feasible approach to management of cN0-pN2 NSCLC without loss of curability. It was unnecessary to convert the VATS approach to thoracotomy in order to do SND even if pN2 disease is revealed during VATS major pulmonary resection. The purpose of this study is to know whether VATS major pulmonary resection with SND for clinical stage IIIA non-small cell lung cancer is possible.

Video-assisted Thoracoscopic Surgery for Stage IIIA Non-Small Cell Lung Cancer

Feasibility of Video-Assisted Thoracoscopic Surgery for Clinical Stage IIIA Non-Small Cell Lung Cancer

The First Affiliated Hospital of Guangzhou Medical University

Guangzhou Medical College

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Video-assisted Thoracoscopic Surgery for Stage IIIA Non-Small Cell Lung Cancer	NCT00862004	Non-small Cell ...	VATS	18 Years - 80 Years	The First Affiliated Hospital of Guangzhou Medical University
Video-assisted Thoracoscopic Surgery for Stage IIIA Non-Small Cell Lung Cancer	NCT00862004	Non-small Cell ...	VATS	18 Years - 80 Years	The First Affiliated Hospital of Guangzhou Medical University
Video-assisted Thoracoscopic Surgery for Stage IIIA Non-Small Cell Lung Cancer	NCT00862004	Non-small Cell ...	VATS	18 Years - 80 Years	The First Affiliated Hospital of Guangzhou Medical University
Video-assisted Thoracoscopic Surgery for Stage IIIA Non-Small Cell Lung Cancer	NCT00862004	Non-small Cell ...	VATS	18 Years - 80 Years	The First Affiliated Hospital of Guangzhou Medical University

Spots Global Cancer Trial Database for systematic node dissection (snd)