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Atorvastatin

Hydroxymethylglutaryl-CoA Reductase Inhibitors

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Atorvastatin will be administered at 80 mg/day for 3 weeks in the time window between diagnostic biopsy and curative surgery

Marcello Maugeri Saccà, MD

This pre-surgical, window-of-opportunity study is designed to investigate whether atorvastatin reduces the proliferation marker Ki-67 via modulation of the Hippo transducer TAZ.

Targeting the Hippo Transducer TAZ in Breast Cancer With Statins

A Phase II, Randomized, Non-comparative, Pre-surgical Study of Atorvastatin or Observation in Ki-67 Positive, TAZ-expressing Early Breast Cancer Patients (TRINACRIA Trial)

Reduced TAZ expression evaluated by IHC when comparing pre- and post-treatment samples. Staining intensity will be graded on a four-grade scale (0: negative, 1: weak, 2: moderate, 3: strong). The final score will be obtained by considering staining intensity, percentage of expressing cells, and localization (nuclear versus cytoplasmic)

Decreased expression of TAZ targets (AXL and CTGF) and Atorvastatin target (HMGCoAR) evaluated by IHC when comparing pre- and post-treatment samples. Staining intensity for all the molecular endpoints analyzed will be graded on a four-grade scale (0: negative, 1: weak, 2: moderate, 3: strong).

Regina Elena Cancer Institute

MD, PhD

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Targeting the Hippo Transducer TAZ in Breast Cancer With Statins	NCT02416427	Breast Neoplasm...	Atorvastatin	18 Years - 75 Years	Regina Elena Cancer Institute
Targeting the Hippo Transducer TAZ in Breast Cancer With Statins	NCT02416427	Breast Neoplasm...	Atorvastatin	18 Years - 75 Years	Regina Elena Cancer Institute

Spots Global Cancer Trial Database for taz

Every month we try and update this database with for taz cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for taz

Every month we try and update this database with for taz cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for taz cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.