Symptoms and General Pathology

All Conditions

Digestive System Diseases

Diarrhea

Enteritis

Signs and Symptoms, Digestive

Gastroenteritis

Gastrointestinal Diseases

Intestinal Diseases

Gastrointestinal Agents

All Drugs and Chemicals

Analgesics

Antitussive Agents

Central Nervous System Depressants

Respiratory System Agents

Herbal and Botanical

Loperamide

Antidiarrheals

Opium

Opium Poppy

Treamtment with opii normata in case of diarrhea

Treatment with Loperamid in case of diarrhea

After beginning of diarrhea grade 1:

5 drops tincture of opium three times a day

After beginning of diarrhea grade 2:

Intensive therapy with 15 drops tincture of opium three times a day.

Opii normata treatment

All patients who receive as a result of randomisation loperamide

After beginning of diarrhea grade 1:

Initial 4mg and 2mg after any unformed stool. The maximum dose amounts to16mg per day.

After beginning of diarrhea grade 2:

Intensive therapy with 2mg loperamide every 2 h. The maximum dose amounts to 16mg per day.

Loperamid Treatment

Michael Bieker, MD

Therapy-associated diarrhea during radiation therapy of small pelvis (including enteritis as a result of radiation therapy and enteritis as a result of radiation- and chemotherapy) is a common problem in multimodal cancer therapy. We investigate the therapeutic effect of either loperamide or tinctura opii in therapy- associated diarrhea in patients who receive radiation therapy of the small pelvis with or without chemotherapy.

Comparision between treatment with Tinctura Opii normata and Loperamid in patients with therapy-associated diarrhea during radiaton therapy of small pelvis

Prospective Randomized Open Label Study of the Treatment of Therapy-associated Diarrhea During Percutaneous Radiation Therapy of the Small Pelvis. - Comparison of Loperamide and Tincture of Opium -

Prospective Randomized Open Label Study of the Treatment of Therapy-associated Diarrhea During Percutaneous Radiation Therapy of the Small Pelvis. - Comparison of Loperamide and Tincture of Opium

In this study efficacy of loperamide and tincture of opium is linked to the respective proportions of patients where diarrhoea of grade \> 2 is successfully averted during (cancer) therapy.

Quality of life will be assessed with the EORTC-QLQ C30 questionnaire

The quality and quantity of diarrhea will be assessed with a questionnaire

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Prospective Randomized Open Label Study of the Treatment of Therapy-associated Diarrhea During Percutaneous Radiation Therapy of the Small Pelvis. - Comparison of Loperamide and Tincture of Opium -	NCT00444093	Diarrhea Enteritis Cancer	Opii normata tr... Loperamid Treat...	18 Years -	Philipps University Marburg Medical Center
Prospective Randomized Open Label Study of the Treatment of Therapy-associated Diarrhea During Percutaneous Radiation Therapy of the Small Pelvis. - Comparison of Loperamide and Tincture of Opium -	NCT00444093	Diarrhea Enteritis Cancer	Opii normata tr... Loperamid Treat...	18 Years -	Philipps University Marburg Medical Center

Spots Global Cancer Trial Database for therapy associated enteritis