Symptoms and General Pathology

All Conditions

Wounds and Injuries

Rare Diseases

Recurrence

Hyperthermia

Fever

Disease Attributes

Thymic Epithelial Tumor

Antineoplastic Agents

All Drugs and Chemicals

Doxorubicin

Liposomal doxorubicin

Cisplatin

HITOC group contains all patients who undergo HIROC in this study.

Doxorubicin(dose: 25mg/m2) + Cisplatin(dose: 50mg/m2).

HITOC

Jianyong Ding, MD

Hyperthermic intrathoracic chemotherapy (HITOC) offers an additional treatment option for malignant pleural tumors after surgical cytoreduction. Especially it is used to further improve local tumor control in thymic malignancies with pleural spread, who underwent multimodality therapy including surgical resection. A phase II clinical study was conducted to explore the efficacy and safety of surgery followed by HITOC (POD1: DOX, POD2: cisplatin) for thymic epithelial tumors with pleural spread or recurrence.

Intrathoracic Chemotherapy for TETs With Pleural Spread or Recurrence

Cytoreductive Surgery and Hyperthermic Intrathoracic Chemotherapy for the Treatment of Thymic Epithelial Malignancies With Pleural Spread or Recurrence (CHOICE): a Prospective, Open, Single-arm Study Choice

Postoperative hospital stay is the duration for every enrolled patient until the date of meeting the criteria of hospital discharge since the date of surgery.

The criteria of hospital discharge were defined as with the volume of postoperative drainage \< 200 ml/day, a normal chest X-ray, and good physical condition.

Number and severity of adverse events that are related to the treatment of each patient. Postoperative treatment-related complications were assessed by the Clavien-Dindo Classification. Treatment-related adverse events as assessed by CTCAE v5.0.

Overall quality of life is respectively evaluated at randomization and 1 month, 3 month, 6 month after surgery among patients by using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C-30 Scale (EORTC QLQ-C30) (V3.0).

The minimum value of EORTC QLQ-C30 score was 0， and the maximum was 100. Zero indicates the worst quality of life, while 100 represents the best quality of life.

the cumulative daily pain score at rest using VAS from postoperative 0 to 72 hours. The minimum value of the VAS score was 0，and the maximum was 10. Zero indicates the least painful, while 1 represents the worst. The smaller (larger) cumulative daily pain score represents the less (more) pain.

The volume of postoperative drainage of the patient was the sum of his daily drainage volume after the surgery. The types of drainage equipment include the thorax close drainage equipment and the unidirectional negative-pressure drainage ball.

the duration from the date of S-HITOC to the date of the first progression. Disease progression is defined as locoregional (anterior mediastinal area, lung, pericardiac metastasis or pleural progression) or metastatic (supraclavicular lymph nodes or distant organs).

the duration from the date of S-HITOC to the date of the death.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Intrathoracic Chemotherapy for TETs With Pleural Spread or Recurrence	NCT05446935	Thymic Epitheli...	HITOC	16 Years - 80 Years	Shanghai Zhongshan Hospital
Intrathoracic Chemotherapy for TETs With Pleural Spread or Recurrence	NCT05446935	Thymic Epitheli...	HITOC	16 Years - 80 Years	Shanghai Zhongshan Hospital

Spots Global Cancer Trial Database for thymic epithelial malignancies