Neoplasms

Digestive System Diseases

All Conditions

Rare Diseases

Stomach Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Stomach Diseases

Stomach Cancer

The patients in DS group underwent Delta-shaped anastomosis after TLDG.

The patients in B-II group underwent Billroth-II anastomosis after TLDG.

Delta-shaped anastomosis

Billroth II anastomosis

Quan Wang, Doctor

To compare the safety and feasibility of Delta-shaped anastomosis and Billroth II anastomosis after totally laparoscopic distal gastrectomy for gastric cancer(TLDG).

Methods: 78 consecutive patients who underwent TLDG in First Hospital of Jilin University between October 2012 and December 2014 were enrolled in this study . All patients were divided randomly into two groups:Delta-shaped anastomosis group (DS group) and Billroth II anastomosis group (B-II group), and the patients in DS group underwent Delta-shaped anastomosis after TLDG, and the patients in B-II group underwent Billroth-II anastomosis after TLDG.Outcome measures,resected margin,operative time,anastomosis time,number of stapler cartridges used,length of the incision,the time of first flatus and liquid diet,hospital stay and postoperative morbidity are compared between the two groups.

Comparison of Delta-Shaped and Billroth II After TLDG

Comparison of Delta-Shaped and Billroth II for Intracorporeal Anastomosis After Totally Laparoscopic Distal Gastrectomy for Gastric Cancer

Major complications includes anastomosis leakage and intrabdominal bleeding . Minor complications includes bile regurgitation,anastomotic stenosis and delayed gastric emptying.

The First Hospital of Jilin University

Deputy Director of General Surgery

Symptoms and General Pathology

Postoperative Complications

patients in this arm will receive totally laparoscopic distal gastrectomy

patients in this group will receive laparoscopy-assisted distal gastrectomy

all the surgical procedure would be finished under laparoscopy

totally laparoscopic distal gastrectomy

Xubing Zhang

This study was designed as a randomized clinical trial comparing the totally laparoscopic distal gastrectomy with laparoscopy-assisted distal gastroectomy for patients with gastric cancer, in terms of short-term and long-term outcomes.

When one patient was enrolled, he will be randomly divided into experimental group (totally laparoscopic distal gastrectomy) or control group (laparoscopy-assisted distal gastrectomy). When he receives surgery, intraoperative parameters would be recorded. when the patient discharges, the routine follow-up would be regularly performed for the survival.

the Outcomes Assessor would not know which approach the patient received.

Totally Laparoscopic Distal Gastrectomy for Gastric Cancer

Randomized Controlled Trial Comparing the Outcomes of Totally Laparoscopic Distal Gastrectomy and Laparoscopy-assisted Gastrectomy for Gastric Cancer

there is a plan to make individual participant data (IPD) available to other researchers.

the time from the finish of surgery to discharge

the survival rate at the third year from the finish of surgery

Liu Liu

Clinical professor

Behaviors and Mental Disorders

Adenocarcinoma

Esophageal Neoplasms

Carcinoma

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Head and Neck Neoplasms

Esophageal Diseases

Quality of Life

Esophageal Cancer

Performing totally laparoscopic proximal gastrectomy with esophagogastrostomy by fissure technique

Surgical Operation:

1. Gastric Resection Range:Proximal gastrectomy, preserving 2/3 of the distal stomach.
2. Lymph Node Dissection Range:D1+ to D2 lymph node dissection.
3. Anastomosis Method: esophagogastrostomy by fissure technique.
4. Anastomosis Risk Management Plan:For a rupture with a maximum diameter less than or equal to 5mm, repair with 4-0/3-0 absorbable sutures and proceed with the anastomosis.For a rupture with a maximum diameter greater than 5mm or failed anastomosis, resect that part of the remaining stomach, change to proximal gastrectomy, and perform double-channel anastomosis.
5. Surgical Approach:Totally laparoscopic proximal gastrectomy.

Hankun Hao, doctor

This is a single-center, open-label, Phase Ib/II study aiming to assess the perioperative safety and postoperative outcomes of a novel surgical technique in treating primary adenocarcinoma located in the upper 1/3 of the stomach or gastroesophageal junction (Siewert II or III).

The study will enroll 30 patients who will undergo totally laparoscopic proximal gastrectomy with esophagogastrostomy by fissure technique. Clinical data will be collected to evaluate perioperative safety. Patients will be followed for at least 3 months, during which endoscopy will be performed to analyze occurrences and reasons for anastomotic-related complications. Additionally, the quality of life after surgery will be evaluated by QLQ-C30 and QLQ-STO22.

Patients included in this group will receive totally laparoscopic proximal gastrectomy with esophagogastrostomy by fissure technique，which is an innovative surgery that investigators first began to apply in patients with proximal gastric cancer.

A Prospective Study on Esophagogastrostomy by an Innovative Surgical Technique

A Prospective Study on the Perioperative Safety and Short-Term Quality of Life in Totally Laparoscopic Proximal Gastrectomy With Esophagogastrostomy by Fissure Technique

Time spent on the whole operation（minutes）

Time to remove the drain tube,flatus, to liquid diet, and soft diet are used to assess the postoperative recovery course, which is a composite outcome measure.

AJCC（American Joint Committee on Cancer）-8th TNM staging system will be used to obtain pathology of tumor .

Patients will be monitored for the incidence of postoperative reflux esophagitis after surgery by weight changes, blood biochemistry and endoscopic examination

QLQ-C30 is a comprehensive assessment of the overall quality of life dimensions before and after surgery for patients. Higher scores represent poorer quality of life for patients after surgery.

QLQ-STO22 is a specific assessment for postoperative situations related to anastomosis, such as swallowing and eating.Higher scores represent poorer quality of life for patients after surgery.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Comparison of Delta-Shaped and Billroth II After TLDG	NCT02372747	Gastric Cancer	Delta-shaped an... Billroth II ana...	-	The First Hospital of Jilin University
Totally Laparoscopic Distal Gastrectomy for Gastric Cancer	NCT05556980	Postoperative C...	totally laparos...	18 Years - 80 Years	The First Affiliated Hospital of University of Science and Technology of China
Totally Laparoscopic Distal Gastrectomy for Gastric Cancer	NCT05556980	Postoperative C...	totally laparos...	18 Years - 80 Years	The First Affiliated Hospital of University of Science and Technology of China
A Prospective Study on Esophagogastrostomy by an Innovative Surgical Technique	NCT06300879	Gastric Cancer Adenocarcinoma ...	Performing tota...	18 Years - 75 Years	Huashan Hospital

Spots Global Cancer Trial Database for totally laparoscopic gastrectomy