Neoplasms

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Digestive System Diseases

Wounds and Injuries

Rare Diseases

Carcinoma

Esophageal Neoplasms

Surgical Wound

Gastrointestinal Neoplasms

Digestive System Neoplasms

Head and Neck Neoplasms

Gastrointestinal Diseases

Esophageal Diseases

Esophageal Cancer

Dermatologic Agents

All Drugs and Chemicals

Menthol

Via minimally invasive thoracol-laparoscopic esophagectomy.

Via traditional three incisions esophagectomy.

Minimally invasive thoracol-laparoscopic esophagectomy will be performed in this group.

Patients will be treated with traditional three incisions esophagectomy.

Jie He, MD

Juwei Mou, MD

Deruo Liu, MD

Keneng Chen, MD

Tiansheng Yan, MD

Hui Li, MD

Ming Du, MD

Ming Du

Rongyu Xu

Zhaoke Wen

Jianping Liang, MD

Minxin Shi

Quan Xu

Shun Xu

Yongtao Han

This study is a multi-center, randomized, and open-label trial to compare the safety and feasibility of traditional three incisions and minimally invasive thoracol-laparoscopic esophagectomy for esophageal cancer.

Traditional Three Incisions vs Minimally Invasive Thoracol-laparoscopic Esophagectomy for Esophageal Cancer

Traditional Three Incisions vs Minimally Invasive Thoracol-laparoscopic Esophagectomy for Esophageal Cancer: a Multi-center, Randomized, and Open-label Trial

The presence of inflammatory factors and stress response indicators (ATCH, C- reactive protein, interleukin-6, etc.)of esophageal tissue specimens and blood samples will be explored

Respiratory complications including respiratory failure requiring mechanical ventilation, atelectasis needs suctioning of bronchoscopy, lung infection needs medication, adult respiratory distress syndrome.

To observe differences of short-term effects(bleeding volume during operation,operation time, hospital mortality, 2 years DFS) between two groups.

Surgical Complications except respiratory complications(such as infection, esophageal fistula, etc.) will be measured by the Clavien-Dindo Classification

lung function will be measured by VC,FVC,FEV1,DLCO

Pain Scores will be measured by Brief pain inventory(BPI)

HRQoL will be measured by EORTC QLO-C30, QLQ-OES18

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Traditional Three Incisions vs Minimally Invasive Thoracol-laparoscopic Esophagectomy for Esophageal Cancer	NCT02355249	Esophageal Carc...	MIE OE	18 Years - 75 Years	ChineseAMS
Traditional Three Incisions vs Minimally Invasive Thoracol-laparoscopic Esophagectomy for Esophageal Cancer	NCT02355249	Esophageal Carc...	MIE OE	18 Years - 75 Years	ChineseAMS

Spots Global Cancer Trial Database for traditional three incisions