Infections

All Conditions

Symptoms and General Pathology

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Communicable Diseases

Papillomavirus Infections

Sexually Transmitted Diseases

Sexually Transmitted Diseases, Viral

Virus Diseases

DNA Virus Infections

Tumor Virus Infections

Genital Diseases

Urogenital Diseases

Disease Attributes

Participants will have a clinician-collected cervical screening sample and then collect the following self-samples for research: Vaginal swab, Anal swab, Oral rinse, and Urine sample for the detection of HPV detection.

Participants will collect the following self-samples for research in the clinic: Vaginal swab, Anal swab, Oral rinse, and Urine sample for the detection of HPV detection. Participants will collect the following self-samples for research at home: Vaginal swab, Anal swab, and Oral rinse sample for the detection of HPV detection.

HPV DNA methylation assay to detect HPV positivity, HPV genotype, and HPV methylation.

HPV DNA methylation assay

Alison M Berner

Sophie Ross

Lisa Barbour

James Hand

Kyle Ring

Lucy Campbell

Ellen Adams

Sarah S Jackson, PhD

Alison M Berner, MBBS, PhD

Human papillomavirus (HPV) is a common virus that spreads through skin-to-skin contact. Some HPV types can cause changes in cells that lead to cancer and are known as 'high-risk' HPV (hrHPV). hrHPV is linked to cancers of the cervix (opening of the womb), throat, and anus (exit of the bowel).

It is not known if transgender people (individuals whose gender identity does not align with their sex assigned at birth) are at increased risk of hrHPV or cancers caused by hrHPV compared to cisgender people (individuals whose gender identity does align with their birth sex). There is also little knowledge about HPV in the vagina for transgender women who have surgery to make one.

Transgender men may be at higher risk of cervical cancer than cisgender women because they are less likely to go for screening. This can be because of physical discomfort and emotional distress during screening when a swab is taken directly from the cervix.

The investigators seek to examine how common hrHPV is in transgender people in different parts of the body. In the study, participants will take swabs from the vagina and anus, a urine sample, and use mouthwash. Transgender men will also have an extra swab taken by a clinician as part of routine cervical screening. This is to see if the swab from the vagina is as good as the one from the cervix for finding cells that might lead to cancer. Participants will also take an online survey to measure the acceptability of self-sampling compared to clinician sampling.

This research can inform HPV prevalence and decision-making about HPV screening among transgender people.

Transgender and gender diverse identities.

HPV Self-testing in Transgender Individuals

HPV Methylation Self-testing Pilot in Transgender Individuals

HPV correlation between self-samples at each site (vaginal, anal, oral, and urine) in each arm.

Comparison of the performance of HPV methylation testing from self-collected samples to clinician-collected samples for the detection of cervical precancer in trans men and non-binary adults with a cervix.

Feasibility of self-sampling in clinic as measured by the proportion of completed and returned self-samples.

Acceptability of self-sampling in clinic as indicated by high satisfaction on an online survey

Feasibility of self-sampling at home as measured by the proportion of completed and returned self-samples.

Acceptability of self-sampling at home as indicated by high satisfaction on an online survey

Concordance HPV positivity, overall and by genotype, from self-collected vaginal samples to clinician-collected cervical samples in trans men and nonbinary adults with a cervix.

HPV correlation between self-samples taken at clinic and in-home among trans women and non-binary people.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
HPV Self-testing in Transgender Individuals	NCT05883111	HPV Infection	HPV DNA methyla...	21 Years - 65 Years	Queen Mary University of London
HPV Self-testing in Transgender Individuals	NCT05883111	HPV Infection	HPV DNA methyla...	21 Years - 65 Years	Queen Mary University of London

Spots Global Cancer Trial Database for trans women

Every month we try and update this database with for trans women cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for trans women

Every month we try and update this database with for trans women cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for trans women cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.