Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Lung Neoplasms

Multiple Pulmonary Nodules

Solitary Pulmonary Nodule

The guide sheath(GS) is introduced into the lesion via Electromagnetic Navigation System. The locatable guide(LG) and GS are confirmed to reach the lesion by radiograph fluoroscopy, pathologic specimens are obtained with fluoroscopic guidance.

The GS is introduced into the lesion via the working channel of a bronchoscope with radiographic fluoroscopy. Once the location of the lesion is identified by fluoroscopy, pathologic specimens are obtained under fluoroscopic guidance.

ENB is performed using an electromagnetic navigation system (LK-DW-NK-Z; Suzhou Lungcare Medical Technology Inc., China) with an internal locatable guide (LG; Lungcare) with diameter of 1.45 mm. Bronchoscopes with a working channel diameter of 2.0 mm are used (BF-260 and BF-P260F; Olympus, Japan). The LG is inserted into the GS(K-201; Olympus) beforehand, and the GS-covered LG is introduced via the working channel of the bronchoscope and navigated to the PPL finally. The LG and GS are confirmed to reach the lesion by radiograph fluoroscopy.

A GS is introduced in the working channel of the bronchoscope alone. The GS is confirmed to reach the lesion by radiograph fluoroscopy, pathologic specimens are obtained under fluoroscopic guidance.

GS-TBLB-X-ray

Jiayuan Sun, MD

The purpose of this study is to evaluate the efficacy and safety of electromagnetic navigation bronchoscopy with a Guide Sheath(ENB-GS) for the diagnosis of peripheral pulmonary lesions (PPLs) .

The investigators evaluated the efficacy and safety of transbronchial lung biopsy (TBLB) and bronchial brushing using electromagnetic navigation bronchoscopy (ENB) with a guide sheath (GS) for the diagnosis of peripheral pulmonary lesions (PPLs) with radiographic fluoroscopy.The study is designed as a two-center prospective randomized controlled trial. The participating centers are Department of pulmonary medicine and endoscope department, Shanghai chest Hospital affiliated to Shanghai JiaoTong University, China. Department of pulmonary medicine, Shanghai ZhongShan Hospitial affiliated to Shanghai FuDan University, China.Patients are divided into two groups, ENB-GS-TBLB-X-ray group and GS-TBLB-X-ray group.Each subject will be randomized to each group.The study is expected to enroll 60 patients at 2 centers (Shanghai Chest Hospital: 40, Shanghai Zhongshan Hospital: 20).

ENB-GS-TBLB for the Diagnosis of PPLs

Diagnostic Value of Electromagnetic Navigation Bronchoscopy With a Guide Sheath for Peripheral Pulmonary Lesions : a Randomized Controlled Trial

The diagnostic yield in the ENB-GS-TBLB and GS-TBLB group was 87.2% and 61% individually.

Including total procedure time，total X-ray time, duration time for finding lesions and X-ray time for finding lesions.

Fudan University

Shanghai Chest Hospital

Director, Endoscope Center, Shanghai Chest Hospita

The guide sheath(GS) is introduced into the lesion via Electromagnetic Navigation System. The locatable guide(LG) and GS are confirmed to reach the lesion by radiograph fluoroscopy, pathologic specimens are obtained with fluoroscopic guidance.

GS-TBLB-X-ray: A GS is introduced in the working channel of the bronchoscope alone. The GS is confirmed to reach the lesion by radiograph fluoroscopy, pathologic specimens are obtained under fluoroscopic guidance.

ENB-GS-TBLB-X-ray Group

The GS is introduced into the lesion via the working channel of a bronchoscope with radiographic fluoroscopy. Once the location of the lesion is identified by fluoroscopy, pathologic specimens are obtained under fluoroscopic guidance.

GS-TBLB-X-ray: A GS is introduced in the working channel of the bronchoscope alone. The GS is confirmed to reach the lesion by radiograph fluoroscopy, pathologic specimens are obtained under fluoroscopic guidance.

GS-TBLB-X-ray Group

Total

Age, Continuous

Sex: Female, Male

lesion size(long axis)

lesion size(short axis)

Upper Lobes

Middle Lobes

Lower lobes

lesion location

distance of the nodule to the pleural surface

distance from the lesion to the pleural

The bronchus sign on CT represents the presence of a bronchus leading directly to a peripheral pulmonary lesion.

bronchus sign

Dr. Jiayuan Sun

Diagnosed by TBLB

Not Diagnosed by TBLB

The Difference of Diagnostic Value of ENB-GS-TBLB as Compared to GS-TBLB

Total procedure time

Total X-ray time

Duration time for finding lesion

X-ray time for finding lesion

The Duration Time Difference of ENB-GS-TBLB With Fluoroscopy as Compared to GS-TBLB With Fluoroscopy Alone

The guide sheath(GS) is introduced into the lesion via Electromagnetic Navigation System.

ENB: ENB is performed using an electromagnetic navigation system (LK-DW-NK-Z; Suzhou Lungcare Medical Technology Inc., China) with an internal locatable guide (LG; Lungcare) with diameter of 1.45 mm. Bronchoscopes with a working channel diameter of 2.0 mm are used (BF-260 and BF-P260F; Olympus, Japan). The LG is inserted into the GS(K-201; Olympus) beforehand, and the GS-covered LG is introduced via the working channel of the bronchoscope and navigated to the PPL finally. The LG and GS are confirmed to reach the lesion by radiograph fluoroscopy.

GS-TBLB-X-ray: A GS is introduced in the working channel of the bronchoscope alone. The GS is confirmed to reach the lesion by radiograph fluoroscopy, pathologic specimens are obtained under fluoroscopic guidance.

Overall Study

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

TBNA + transbronchial lung biopsy + bronchial washing

The main purposes of this study are to assess the performance characteristics of transbronchial needle aspiration (TBNA) in the diagnosis of peripheral pulmonary lesions, and to identify the predictor variables of a positive aspirate.

In a recent systematic literature review (Rivera PM, Mehta AC; Chest 2007; 132: 1318-1488) TBNA showed the highest sensitivity in the diagnostic bronchoscopic approach to peripheral pulmonary lesions, as compared to the other available sampling techniques (transbronchial biopsy, brushing, washings). However, the Authors conclude that the data regarding TBNA in this setting deserve cautious interpretation because of the limited number of studies and the large differences in sample size). We designed the present study to assess the performance characteristics of TBNA, alone and in comparison with those of transbronchial biopsy, in the diagnosis of peripheral pulmonary lesions.

Transbronchial Needle Aspiration in the Diagnosis of Peripheral Pulmonary Malignancy

Transbronchial Needle Aspiration in the Diagnosis of Peripheral Pulmonary Malignancy: Yield and Predictors of a Positive Aspirate

Maggiore Bellaria Hospital, Bologna

Marco Patelli

Cryo biopsy

Felix JF Herth, MD, PhD

Ralf Eberhardt, MD

Felix JF Herth, MD, Phd

To proof the feasibility and safety of EBUS guided transbronchial cryo biopsies in peripheral lung lesions

Solitary pulmonary nodule are a diagnostic dilemma. Nowadays not only the basic tissue diagnosis is necessary, molecular signals are state of the art. Therefore more tissue is necessary. With a cryoprobe the amount of tissue is increased compared to the classical forceps biopsy.

Until now, the use of the cryoprobe ism´t show in peripheral lung tissue.

EBUS Guided Cryo Biopsy of Solitary Pulmonary Nodules

Number of Participants with Adverse Events as a Measure of Safety Detailed analysis of number of Pneumothoraces and number of bleeding complication

Diagnostic yield of the different biopsy techniques in establishing a specific diagnosis of the lesion

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
ENB-GS-TBLB for the Diagnosis of PPLs	NCT02207478	Lung Cancer	ENB GS-TBLB-X-ray	18 Years - 80 Years	Shanghai Chest Hospital
Transbronchial Needle Aspiration in the Diagnosis of Peripheral Pulmonary Malignancy	NCT00917137	Pulmonary Nodul... Pulmonary Mass	TBNA + transbro...	18 Years - 76 Years	Maggiore Bellaria Hospital, Bologna
EBUS Guided Cryo Biopsy of Solitary Pulmonary Nodules	NCT01221493	Yield of Cryo B... Solitary Pulmon...	Cryo biopsy	40 Years - 80 Years	Heidelberg University

Spots Global Cancer Trial Database for transbronchial lung biopsy