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Spots Global Cancer Trial Database for Retrospective Registry Study of Patients With Cancer Treated With High-dose Methotrexate

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Retrospective Registry Study of Patients With Cancer Treated With High-dose Methotrexate

Official Title: High-dose Methotrexate Patterns of Use, Clearance, Toxicities, Supportive Care and Outcomes

Study ID: NCT05899751

Study Description

Brief Summary: This retrospective observational study will evaluate high-dose methotrexate patterns of use, supportive care measures used during high-dose methotrexate chemotherapy, along with the incidence of delayed elimination of methotrexate, acute kidney injury and any associated impact of delayed elimination of methotrexate on future courses of chemotherapy and disease outcomes in adults and children with cancer. The study will compare current practice with existing guidelines and best practices to identify potential gaps in the management of high-dose methotrexate administration and delayed elimination of methotrexate. The study will identify variations in practice and outcomes in different study centers, countries, cancer types, patient age groups, by different methotrexate doses and infusion times and different supportive care measures used. The study will also document the proportion of high-dose methotrexate courses in which glucarpidase has been used and any toxicities attributable to the use of glucarpidase.

Detailed Description:

Eligibility

Minimum Age:

Eligible Ages: CHILD, ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Assistance Publique Hôpitaux de Marseille (APHM), La Timone Hospital, Marseille, , France

University of Milan-Bicocca, Monza, , Italy

Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca (VHIR), Barcelona, , Spain

Fundación Privada Instituto de Investigación Oncológica de Vall d'Hebron (VHIO), Barcelona, , Spain

Hospital Universitario Reina Sofía, Córdoba, , Spain

Contact Details

Name: Carmelo Rizzari, MD

Affiliation: University of Milano-Bicocca, Pediatric Hematology Oncology Unit MBBM Foundation

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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