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Spots Global Cancer Trial Database for Leukemia Cell Cultures for Research of New Anti-Cancer Therapies

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Trial Identification

Brief Title: Leukemia Cell Cultures for Research of New Anti-Cancer Therapies

Official Title: Leukemia Cell Cultures for Research of New Anti-cancer Therapies

Study ID: NCT00993538

Conditions

Acute Leukaemia

Study Description

Brief Summary: The main objective of this project is not only a better understanding of the human leukemic disease but also to find new anti-leukemic or improve existing ones. This study has, the following aims: * To analyze the genetic and epigenetic regulation of the retinoic acid induced cascade which leads to the expression of TRAIL in blood cells of patients with acute leukemia. This study will be complemented by the analysis of global gene expression (DNA chips) and of the DNA methylation state, and by chromatin immunoprecipitation experiences. * To determine the efficiency of inhibitors of enzymes responsible for the modification of chromatin (existing and new developments within the European consortium EPITRON coordinated by Dr Gronemeyer) as inducers of differentiation and / or apoptosis of leukemic blasts. * To explore Ikaros genic and functional abnormalities (genomic deletions, mutations, abnormal transcripts and proteins) in acute leukemia. The aim is to determine if these abnormalities may play a prognosis role.

Detailed Description:

Eligibility

Minimum Age: 28 Days

Eligible Ages: CHILD, ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Service d'Hématologie et d'Oncologie, Strasbourg, , France

Service de Pédiaterie - Hôpital de Hautepierre, Strasbourg, , France

Contact Details

Name: Raoul Herbrecht, MD

Affiliation: Département d'Hématologie et d'Oncologie-hôpital de Hautepierre Strasbourg, France

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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