Spots Global Cancer Trial Database for A Retrospective Study of Patients With Leukemia Relapse in the CNS Treated With CAR T Cells
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Trial Identification
Brief Title: A Retrospective Study of Patients With Leukemia Relapse in the CNS Treated With CAR T Cells
Official Title: CARs for CNS-Leukemia Relapse: A Retrospective International Study
Study ID: NCT04158011
Conditions
Interventions
Study Description
Brief Summary: CAR T cells targeting CD19 have been approved for patients with relapsed or refractory ALL, failing two or more prior protocols. Several institutional-based studies with other CAR T cells targeting CD19 have demonstrated outstanding response rates in patients with refractory disease, and the ability of CAR T cells to clear CNS leukemia. Nevertheless, these cases are sparse and have never been reported collectively. Here, we aim to retrospectively assess toxicity and long term outcome of patients treated with CAR T cells for CNS relapse of ALL.
Detailed Description:
Keywords
Eligibility
Minimum Age:
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Chaim Sheba Medical Center, Ramat Gan, , Israel
Contact Details
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