Spots Global Cancer Trial Database for HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation With Reduced Dose Post Transplantation Cyclophosphamide GvHD Prophylaxis
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Trial Identification
Brief Title: HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation With Reduced Dose Post Transplantation Cyclophosphamide GvHD Prophylaxis
Official Title: A Phase II Study of Reduced Dose Post Transplantation Cyclophosphamide as GvHD Prophylaxis in Adult Patients With Hematologic Malignancies Receiving HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation
Study ID: NCT06001385
Study Description
Brief Summary: The goal of this clinical trial is to determine the effectiveness of Reduced Dose Post-Transplant Cyclophosphamide (PTCy) in patients with hematologic malignancies after receiving an HLA-Mismatched Unrelated Donor (MMUD) . The main question\[s\] it aims to answer are: * Does a reduced dose of PTCy reduce the occurrence of infections in the first 100 days after transplant? * Does a reduced dose of PTCy maintain the same level of protection against Graft Versus Host Disease (GvHD) as the standard dose of PTCy?
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
City of Hope, Duarte, California, United States
Mayo Clinic - Jacksonville, Jacksonville, Florida, United States
University of Miami Sylvester Cancer Center, Miami, Florida, United States
Moffitt Cancer Center, Tampa, Florida, United States
Dana Farber Cancer Institute, Boston, Massachusetts, United States
Karmanos Cancer Institute, Detroit, Michigan, United States
University of Minnesota, Minneapolis, Minnesota, United States
Barnes Jewish Hospital / Washington University, Saint Louis, Missouri, United States
Memorial Sloan Kettering Cancer Center - Adults, New York, New York, United States
University of North Carolina, Chapel Hill, North Carolina, United States
Oregon Health & Science University, Portland, Oregon, United States
Abramson Cancer Center, Philadelphia, Pennsylvania, United States
MD Anderson Cancer Center, Houston, Texas, United States
University of Virginia Health System, Charlottesville, Virginia, United States
Fred Hutchinson Cancer Center, Seattle, Washington, United States
Froedtert & the Medical College of Wisconsin, Milwaukee, Wisconsin, United States
Contact Details
Name: Steven Devine, MD
Affiliation: NMDP
Role: PRINCIPAL_INVESTIGATOR
Name: Jeffery Auletta, MD
Affiliation: NMDP
Role: STUDY_CHAIR
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